ArticlePloS one2025
Risk factors for perioperative nerve injury associated with total knee arthroplasty: Analysis of a national administrative database.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- [PROMs as instruments for outcome assessment after total knee arthroplasty in three different EndoCert-Certified institutional surgical settings].Orthopadie (Heidelberg, Germany) · 2026Article
- Nerve Injuries After Total Hip Arthroplasty: A Systematic Review and Meta-Analysis.Orthopedic reviews · 2026Article
- Nerve Injuries After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.Orthopedic reviews · 2026Article
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Authors and funding
6 authors.
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Abstract
introductionNerve injury related to total knee arthroplasty (TKA) is a rare but serious complication. Previous studies identifying risk factors for nerve injury related to TKA have been constrained by institutional data or small cohorts. The current study utilized a comprehensive, national, administrative database to investigate independent risk factors for nerve injury associated with TKA. MATERIALS AND
methodsThe PearlDiver M161 database was queried for adult TKA procedures performed between 2010 and 2022. Cases with postoperative nerve injury within 90 days of surgery were identified. Factors such as patient age, sex, body mass index (BMI), Elixhauser Comorbidity Index (ECI), fracture indication, and type of surgery (primary vs. revision) were evaluated for their correlation with nerve injury using multivariate analyses.
resultsOut of 1,517,637 TKA procedures, nerve injury was identified for 4,480 (0.3%). Multivariate analysis identified the following independent risk factors for nerve injury, listed in decreasing order of odds ratio (OR): revision surgery (OR: 1.68), female sex (OR: 1.31), ECI ≥ 5 (OR: 1.27), and younger age (OR: 1.02 per decreasing decade) (P < 0.05 for each). Factors not significantly associated with nerve injury included underweight BMI (<20 kg/m2) and fracture indication. A decreased risk of nerve injury was observed in individuals with a BMI ≥ 35 kg/m2 (OR: 0.80, P = 0.002). DISCUSSION: As expected, the incidence of nerve injury following TKA was low at 0.3%. Independent risk factors were identified for this adverse outcome, with the highest risk associated with revision surgeries. These findings, drawn from the largest cohort studied to date, offer valuable insights for risk stratification, and should inform patient discussions.
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