Evidence map›Paper›PMID 40455650›Full record

ArticleGenes, brain, and behavior2025

Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy.

Julie R Dumont, Paul A S Sheppard, Chris Fodor, M Alexander Coto, Sabrina Yang, Takashi Saito, Takaomi C Saido, R Jane Rylett, Marco A M Prado, Timothy J Bussey and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, brain, and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julie R DumontBrainsCAN, Western University, London, Ontario, Canada.ORCID 0000-0002-2412-306X
Paul A S SheppardRobarts Research Institute, Western University, London, Ontario, Canada.ORCID 0000-0001-7432-1446
Chris FodorBrainsCAN, Western University, London, Ontario, Canada.
M Alexander CotoBrainsCAN, Western University, London, Ontario, Canada.
Sabrina YangBrainsCAN, Western University, London, Ontario, Canada.ORCID 0000-0003-4880-051X
Takashi SaitoDepartment of Neurocognitive Science, Institute of Brain Science, Nagoya City University, Nagoya, Aichi, Japan.ORCID 0000-0002-9659-9251
Takaomi C SaidoRIKEN Center for Brain Science, Wako, Saitama, Japan.ORCID 0000-0003-1970-6903
R Jane RylettDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, BrainsCAN, Robarts Research Institute, London, Ontario, Canada.ORCID 0000-0002-9158-9599
Marco A M PradoDepartment of Physiology and Pharmacology, Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, BrainsCAN, Robarts Research Institute, London, Ontario, Canada.ORCID 0000-0002-3028-5778
Timothy J BusseyDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, BrainsCAN, Robarts Research Institute, London, Ontario, Canada.ORCID 0000-0002-3180-3709
Lisa M SaksidaDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, BrainsCAN, Robarts Research Institute, London, Ontario, Canada.ORCID 0000-0002-8416-8171
Vania F PradoDepartment of Physiology and Pharmacology, Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, BrainsCAN, Robarts Research Institute, London, Ontario, Canada.ORCID 0000-0003-4994-6393

Funding

Canada First Research Excellence Fund
6 · The paper itself

Abstract

Alzheimer's disease is a debilitating neurodegenerative condition characterized by amyloid beta plaques and tau neurofibrillary tangles, which leads to progressive cognitive decline. Several new mouse models of fast amyloid deposition have been generated with compound mutations, but how these affect high-level cognitive function is still not fully understood. Four cohorts of a second-generation amyloid precursor protein knock-in mouse model, App

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorCognitionLearningAnimalsCognitive FlexibilityDisease Models, AnimalFemaleGene Knock-In TechniquesMaleMiceMice, TransgenicPlaque, AmyloidAmyloid beta-Protein PrecursorAPPexecutive dysfunctionextinctionpairwise visual discriminationreversal learning

Identifiers

PMID40455650
PMCPMC12129047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.