Evidence map›Paper›PMID 40455584›Full record

ArticleJournal of the American Society of Nephrology : JASN2025

Macrophage Accumulation and Cyst Expansion in Pkd2 , Ift88 , and Double Mutant Mouse Models.

Zhang Li, Raksha P Hombal, Jun Wang, Sreelakshmi Cherakara, Timothy C Howton, Kurt A Zimmerman, James F Collawn, Reagan S Andersen, Courtney J Haycraft, Mandy J Croyle and 3 more

Abstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Inflammation and Cyst Expansion in Polycystic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhang LiDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-3796-0369
Raksha P HombalDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0009-0009-2121-4124
Jun WangDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.ORCID 0000-0002-3413-5208
Sreelakshmi CherakaraDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0003-2617-3236
Timothy C HowtonDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-9423-0135
Kurt A ZimmermanDivision of Nephrology, Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.ORCID 0000-0003-1798-8046
James F CollawnDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-2528-2759
Reagan S AndersenDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0003-0840-1952
Courtney J HaycraftDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.
Mandy J CroyleDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0001-5208-0530
John M ParantDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.ORCID 0000-0001-9084-5098
Brittany N LasseigneDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-1642-8904
Bradley K YoderDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-0247-1944

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
Injury Response Mediated Pathogenesis in Renal CiliopathiesR01DK115752 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Bradley K. Yoder · 2018 to 2026
$4.0M
Differentiating slow from rapidly progressive ADPKD by cell-specific mitochondrial and transcriptional profilesR01DK134310 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Brittany Nicole Lasseigne · 2024 to 2026
$1.5M
NCI NIH HHS P30 CA013148NIAID NIH HHS P30 AI027767NIDDK NIH HHS R01 DK115752NIDDK NIH HHS R01 DK134310PKDF 214g16aPKDF 959949
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ADPKDmacrophages

Identifiers

PMID40455584
PMCPMC12591675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.