ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2025
Cumulative stress and epigenetic aging: Examining the role of psychological moderators.
Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Work stress and healthy aging: A conceptual framework for the Semmelweis study and the Semmelweis-EUniWell workplace health promotion model program.GeroScience · 2026Review
- Joint effects of social determinants of health on NAFLD mortality: the mediating role of phenotypic age acceleration.GeroScience · 2026Article
- Eudaimonia as Personal Growth: Decades of Research and Needed Future Directions.Behavioral sciences (Basel, Switzerland) · 2026Review
- Review
- Gender differences in the association between marriage and epigenetic age.Frontiers in aging · 2026Article
- Cumulative stress and epigenetic aging: Examining the role of psychological moderators.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveCellular epigenetic aging has become an important marker of healthy or unhealthy aging. The current study examined whether lifelong cumulative stressors across multiple domains were linked with epigenetic age acceleration (EAA; i.e., epigenetic age greater than chronological age) and whether psychological factors moderated this association. Dimensions of psychological well-being were hypothesized as protective factors, while neuroticism was posited as a vulnerability factor.
methodData from the Midlife in the United States (MIDUS) Genomics Project (
resultsThe results revealed that cumulative stressors were not directly associated with EAA but were contingent on the levels of psychological well-being and neuroticism. Specifically, higher levels of cumulative stressors were significantly linked to EAA, measured by GrimAge2, among those who had lower levels of psychological well-being (β = -.23 to -.36,
conclusionsThe findings underscore the importance of considering individual psychological assets and vulnerabilities in the pathways linking cumulative stressors to epigenetic aging. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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