Evidence map›Paper›PMID 40455410›Full record

SynthesisHuman vaccines & immunotherapeutics2025

Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Asia from 2015 to 2021.

Tim Jesudason, Kelly Fleetwood, Maria Bermudez, Oluwaseun Sharomi, Hannah Schirrmacher, Christian Hauck, Daniel Hungerford, David Tordrup, Jelle Matthijnssens, Cristina Carias

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tim JesudasonTriangulate Health Ltd., Doncaster, UK.
Kelly FleetwoodUsher Institute, University of Edinburgh, Edinburgh, UK.
Maria BermudezTriangulate Health Ltd., Doncaster, UK.
Oluwaseun SharomiBiostatistics and Research Decision Sciences (Health Economic and Decision Sciences), Merck & Co., Inc ., Rahway, NJ, USA.
Hannah SchirrmacherTriangulate Health Ltd., Doncaster, UK.
Christian HauckTriangulate Health Ltd., Doncaster, UK.
Daniel HungerfordDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
David TordrupTriangulate Health Ltd., Doncaster, UK.
Jelle MatthijnssensKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, Leuven, Belgium.ORCID 0000-0003-1188-9733
Cristina CariasValue and Implementation, Merck & Co., Inc, Rahway, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding rotavirus prevalence by genotype can inform disease prevention and immunization decision-making. This systematic literature review summarized the genotype-specific prevalence of rotavirus in Asia from 2015 to 2021. We identified surveillance studies using PubMed, Embase, and Scopus databases, and used proportional meta-analysis (with the generic inverse variance method with arcsine transformation and generalized linear mixed models) to summarize genotype prevalence by region. A total of 7,601 studies were screened, and 73 studies from 16 countries were included. Data from 19,935 rotavirus samples reveal that the most common rotavirus genotypes circulating in Asia from 2015 to 2021 were G3P[8] (24%; 95% CI: 19%, 30%), G9P[8] (11%; 95% CI: 7%, 16%), G1P[8] (11%; 95% CI: 8%, 14%) and G2P[4] (8%; 95% CI: 6%, 10%). The results are comparable to estimates from the pre-vaccine licensure period. Surveillance based on sequencing data could help detect more subtle changes and further characterize the rotavirus burden in Asia.

Indexed as

GenotypeRotavirusRotavirus InfectionsAsiaHumansPrevalenceRotavirus VaccinesRotavirus Vaccineschild healthdiarrhoeaepidemiologyRotavirusvaccination

Identifiers

PMID40455410
PMCPMC12915880

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.