ReviewDigestive diseases and sciences2025
Gastrointestinal Manifestations of Common Variable Immunodeficiency: A Mentored Review.
Review in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A case series study of fever-diarrhea-hematochezia triad as the first presentation in plasma EBV DNA-positive diseases.Frontiers in cellular and infection microbiology · 2026Article
- Multidisciplinary Delphi consensus on malignancy screening in patients with common variable immunodeficiency.Frontiers in immunology · 2026Article
- CVID Enteropathy Associated With Chronic Norovirus Infection: Background, Clinical Features, and Therapeutic Aspects.Reviews in medical virology · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCommon variable immunodeficiency (CVID) is an umbrella term for numerous primary immunodeficiency syndromes characterized by B-cell, and sometimes T-cell, impairment. While CVID is commonly associated with recurrent sinopulmonary infections, gastrointestinal (GI) disease-often presenting atypically due to immune dysregulation-can significantly the increase morbidity and mortality of those affected.
objectivesThis review summarizes the diagnostic criteria, epidemiology, and GI manifestations of CVID to increase awareness among general practitioners and gastroenterologists. This review may help facilitate prompt diagnosis and treatment of affected patients.
methodsWe conducted a narrative review of the literature focusing on the GI manifestations of CVID. This review investigates the GI infections, gastric and bowel diseases, liver involvement, and malignancies associated with this immunodeficiency.
resultsThere is no universal definition for CVID, but rather several commonly used diagnostic criteria. Patients with CVID are susceptible to GI infections including those caused by Giardia, norovirus, Salmonella, Campylobacter, and cytomegalovirus. Gastric diseases such as atrophic gastritis and pernicious anemia may present atypically. Bowel involvement may include nodular lymphoid hyperplasia, small intestinal bacterial overgrowth, CVID enteropathy, celiac-like disease, and inflammatory bowel-like colitis. Liver involvement can include autoimmune hepatitis, nodular regenerative hyperplasia, and viral hepatitis. In addition, patients with CVID may have a higher incidence of malignancies such as lymphoma and gastric cancer compared to the general population.
conclusionCVID is associated with a broad spectrum of infectious and noninfectious GI manifestations that can increase the morbidity and mortality of affected patients. Increased awareness of these complications may facilitate earlier diagnosis and effective management.
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Registered trials
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