SynthesisClinical oral investigations2025
Epidemiological trends in enamel hypomineralisation and molar-incisor hypomineralisation: a systematic review and meta-analysis.
Synthesis in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Non- and minimally invasive management of hypersensitivity in molar-incisor hypomineralisation (MIH) at home and in clinical practice: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Epidemiological trends in enamel hypomineralisation and molar-incisor hypomineralisation: a systematic review and meta-analysis.Clinical oral investigations · 2026Pooled it
- Prevalence and association of Molar Incisor Hypomineralization (MIH) in patients presenting dental fluorosis: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Association of hypomineralized second primary molars (HSPM) and hypomineralized primary canines (HPC) with molar-incisor hypomineralization (MIH): a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Clinical performance of glass hybrid and short fiber-reinforced composite restorations in MIH-affected molars: A 60-month split-mouth randomized controlled trial.Clinical oral investigations · 2026Trial
- Clinical comparison of CAD/CAM nanohybrid composite and hybrid ceramic overlays in children with molar-incisor hypomineralisation: a split-mouth prospective randomized clinical trial.Clinical oral investigations · 2026Trial
- Effects of computer-assisted and conventional local anaesthesia on pain and anxiety in children with molar incisor hypomineralisation: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Are childhood diseases associated with Molar-Incisor Hypomineralization? - Results from an observational study.Clinical oral investigations · 2026Observational
- Oral microbiome signatures of molar-incisor hypomineralisation: insights from a pilot study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Comparative label-free quantitative proteomics of hypomineralised second primary molars (HSPM) and molar incisor hypomineralisation (MIH) reveals divergent enamel protein signatures underpinning distinct pathogenic mechanisms.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Remote assessment of caries, MIH, and plaque on intraoral 3D scan images: Findings from the LIFE Child study.Clinical oral investigations · 2026Article
- Trends in the prevalence of molar incisor hypomineralisation between 2018 and 2023: a comparison of two cross-sectional studies in elementary schools in Mexico.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Article
- Prevalence, clinical characteristics, and treatment needs of Molar Incisor Hypomineralization (MIH) in Turkish children: a cross-sectional study.BMC public health · 2026Article
- Molar incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM): do we need to alter terminology and definition? A scoping review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Review
- Comparative assessment of quality, consistency, and reference accuracy of MIH-related clinical information generated by ChatGPT-4o and DeepSeek R1.BMC oral health · 2026Article
- Clinical significance of residual yellow-brown enamel opacities in severe molar incisor hypomineralisation: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- To Bleach or Not to Bleach?-The Role of Bleaching in the Clinical Workflow for the Treatment of Demarcated Opacities in Anterior Teeth.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Article
- Article
- Distribution and Clinical Characteristics of MIH in Schoolchildren From the Central Peruvian Jungle: A Cross‑Sectional Study.International journal of dentistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the prevalence of enamel hypomineralisation (EH), molar-incisor hypomineralisation (MIH), and hypomineralisation affecting the first permanent molars and incisors (M + IH). It was hypothesized that MIH prevalence had not changed significantly over the last two decades.
methodsPublished literature was screened via PubMed, Embase, Google Scholar, and an extensive hand search. A risk of bias assessment (RoB) was conducted. Prevalence estimates were synthesised in a random-effects meta-analysis and reported at the country-level, continent-level, and globally. Subgroup analyses between different MIH diagnosis indices were conducted. Global MIH prevalence trends between 2000 and 2020 were analysed at 5-year intervals.
resultsAmong the 746 retrieved references, 174 were eligible. However, 138 low-to-moderate RoB studies were included. EH global prevalence was estimated at 25.3% (20.0-30.6) across 21 studies from 15 countries. MIH prevalence was 15.5% (14.4-16.6) across 135 studies from 53 countries, with estimates ranging from 0.6 to 46.6%. Among these studies, 60 reported M + IH prevalence, estimated at 6.9% (6.0-7.7). The global MIH prevalence as analysed in 5-year intervals showed a relatively constant prevalence rate with no significant differences across the years. Similarly, MIH prevalence did not differ significantly based on the diagnostic index used.
conclusionEH phenotypes remain globally widespread with uneven distributions. Data doesn't support the postulated change in MIH prevalence. Assessments of all EH phenotypes and data from underrepresented countries are needed for effective dental health monitoring. CLINICAL RELEVANCE: Oral health professionals should systematically and routinely screen for EH/MIH and discuss it with patients, particularly in high prevalence populations.
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