ArticleDiscover mental health2025
Polygenic scores and symptom severity change after internet-delivered cognitive behaviour therapy for depression and anxiety.
Article in Discover mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Prediction of Clinically Meaningful Improvement After Internet-Delivered Cognitive Behavioral Therapy for Depression and Anxiety Disorders: Machine Learning-Based Predictive Model Development and Temporal Validation Study.Journal of medical Internet research · 2026Article
- Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
- Polygenic scores and antidepressant treatment outcomes in major depression: a critical integrative review.Neuroscience applied · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Depressive and anxiety disorders are leading causes of disability globally. Therapist-guided, Internet-delivered cognitive behaviour therapy (ICBT) is an established treatment for depression and anxiety, but a considerable proportion of treated patients do not achieve sufficient improvement. Predicting symptom changes based solely on clinical variables is challenging, and genetic data could offer additional insights into who might benefit most from ICBT. We conducted a study of 2,668 adults (62% women, average age 35.6) from the Swedish MULTI-PSYCH cohort, to investigate the association between polygenic scores (PGS) for eight psychiatric and cognitive traits and symptom change after ICBT. All participants had been diagnosed with depression, panic disorder or social anxiety disorder. The primary outcome was a harmonised symptom score. Using large discovery data sets, PGSs were computed for ADHD, autism spectrum disorder, bipolar disorder, major depressive disorder and schizophrenia, cross-disorder psychopathology, educational attainment, and intelligence. Linear mixed-effects models identified a significant negative association between PGS for educational attainment (PGS-EDU) and symptom severity in the adjusted model (B = - 0.69, p = 0.034), suggesting that a higher PGS-EDU was associated with lower symptom severity. There was also a significant PGS-EDU*time interaction, indicating that PGS-EDU also influenced the symptom change rate. When excluding outliers, these effects remained statistically significant. No other PGSs were statistically significant. Sensitivity analysis showed that self-reported education level provided a stronger association to the outcome than PGS-EDU, indicating that the potential clinical applications of PGS are currently limited. While these results await replication, they could have important implications for how the ICBT could be adapted to suit a wider portion of the population.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.