Evidence map›Paper›PMID 40455123›Full record

ArticleInorganic chemistry2025

Reimagining Pt(II) Anticancer Agents: The Role of Ferrocene in Monofunctional Chemotherapeutic Compounds.

Selma Miguel, Javier Ortín-Fernández, Silvia Gómez-Pastor, María Ángeles Moliné, Pedro A Sánchez-Murcia, Inés Corral, Francisco Sanz-Rodríguez, Ana María González-Vadillo

Abstract read
In one paragraph

Article in Inorganic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Selma MiguelDepartamento de Química, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid 28049, Spain.ORCID 0000-0003-3069-2450
Javier Ortín-FernándezDepartamento de Química, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid 28049, Spain.
Silvia Gómez-PastorDepartamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid 28049, Spain.
María Ángeles MolinéDepartamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid 28049, Spain.
Pedro A Sánchez-MurciaLaboratory for Computer-Aided Molecular Design, Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University Graz, Neue Stiftingtalstrasse 6/III, Graz 8010, Austria.ORCID 0000-0001-8415-870X
Inés CorralDepartamento de Química, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid 28049, Spain.ORCID 0000-0002-9455-4906
Francisco Sanz-RodríguezDepartamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid 28049, Spain.ORCID 0000-0002-9977-6102
Ana María González-VadilloDepartamento de Química Inorgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid 28049, Spain.ORCID 0000-0002-0324-5615

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The side effects and resistance to treatments associated with platinum compounds, such as cisplatin, underscore the present need for novel anticancer agents with improved properties. The development of hybrid drugs, combining two bioactive units, offers a promising approach by synergistically enhancing the biological activity of the two fragments while reducing the resistance of classic drugs. This work presents the synthesis of a novel family of heterobimetallic compounds, featuring a monofunctional Pt(II) complex with amino groups and a

Indexed as

Antineoplastic AgentsCoordination ComplexesFerrous CompoundsMetallocenesOrganoplatinum CompoundsCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMolecular Dynamics SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsCoordination ComplexesferroceneFerrous CompoundsMetallocenesOrganoplatinum Compounds

Identifiers

PMID40455123
PMCPMC12175133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.