Evidence map›Paper›PMID 40454994›Full record

ArticleJournal of bacteriology2025

Environmental pH controls antimicrobial production by human probiotic

Dieu Linh Nguyen, Subhasree Saha, Aswin Thacharodi, Bharat Bhushan Singh, Sonali Mitra, Hackwon Do, Muthiah Kumaraswami

Abstract read
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dieu Linh NguyenCenter for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA.
Subhasree SahaCenter for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA.
Aswin ThacharodiCenter for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA.
Bharat Bhushan SinghCenter for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA.
Sonali MitraCenter for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA.
Hackwon DoDivision of Life Sciences, Korea Polar Research Institute, Incheon, Incheon, Korea.
Muthiah KumaraswamiCenter for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA.ORCID 0000-0002-9959-5598

Funding

Molecular Mechanism of Virulence Regulation in Streptococcus PyogenesR01AI162748 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI KUMARASWAMI, MUTHIAH · 2021 to 2025
$2.8M
Molecular mechanism of streptococcal adaptation to host nutritional defensesR01AI146048 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI KUMARASWAMI, MUTHIAH · 2020 to 2025
$2.0M
Novel translational strategies to combat group B streptococcus infectionsR21AI182870 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI Muthiah Kumaraswami · 2025 to 2026
$444k
National Research Foundation of Korea RS-2024-00441423, PN24170NIAID NIH HHS R01 AI146048NIAID NIH HHS R01 AI162748NIAID NIH HHS R21 AI182870NIH HHS 1R01AI146048,1R01AI162748,1R21AI182870
6 · The paper itself

Abstract

IMPORTANCE: Probiotic bacteria are important tools in combating bacterial infections. Probiotics exert their antimicrobial activity via several mechanisms, including antimicrobial production. However, discrepancies exist between the

Indexed as

Anti-Bacterial AgentsProbioticsStreptococcus salivariusBacterial ProteinsBacteriocinsGene Expression Regulation, BacterialHumansHydrogen-Ion ConcentrationMultigene FamilyQuorum SensingAnti-Bacterial AgentsBacterial ProteinsBacteriocinsantimicrobial activityantimicrobial productiongene regulationpH sensingprobiotic

Identifiers

PMID40454994
PMCPMC12186490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.