ReviewEpigenomics2025
Epigenetic age acceleration and psychosocial stressors in early childhood.
Review in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of adverse childhood experiences on DNA methylation age: a systematic review and meta-analysis.Clinical epigenetics · 2026Pooled it
- Urban-rural disparities in menarcheal timing: a longitudinal cohort study examining social determinants of health (SDOH), screen time, and hormonal influences among adolescent girls in West Bengal, India.BMC public health · 2026Article
- Examining Epigenetic Age in Women with Different Obesity Conditions Using DNA Methylation at theMethods and protocols · 2026Article
- From Genetic Determinism to Epigenetic Regulation: Paradigm Shifts in the Understanding of Neurodevelopmental Disorders.Current issues in molecular biology · 2026Review
- Radiation effects research foundation-a view to the future.Carcinogenesis · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impact of psychosocial stress on mental and physical health is well-documented. Adverse experiences that occur early in life are particularly impactful on later life health. Epigenetic modifications, such as DNA methylation, have been proposed as a possible mechanism to mediate the impact of childhood events on adult health outcomes. The development of epigenetic clocks to estimate epigenetic age has revealed many examples of epigenetic age acceleration (and deceleration) in association with exposure to psychosocial stressors. Furthermore, altered epigenetic aging has been associated with downstream health outcomes. Here studies are discussed that have reported associations of epigenetic aging with early-life exposure to psychosocial stressors, such as childhood abuse and neglect, and with later-life health outcomes, including increased mortality, morbidity, and disease risk. Protective factors that may mitigate the effect of psychosocial stress on epigenetic aging, and possibly enable reversal of epigenetic aging, are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.