ArticleRNA biology2025
Investigation of possible G-quadruplex formation by GU- and GA-rich repeats and their role in translation.
Article in RNA biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Sequence and ionic requirements of pUG fold quadruplexes.RNA biology · 2026Article
- Exploring the Dynamic Changes of Intercellular Connections in Cervical Cancer: Insights From Transcriptomic Data Combined With Single-Cell Sequencing.Human mutation · 2026Article
- Sequence and ionic requirements of pUG fold quadruplexes.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
RNA G-quadruplexes (rG4s) are involved in many aspects of cellular and viral protein expression. rG4s consist of at least two stacks of guanine tetrads that are stabilized by non-Watson-Crick-Franklin base pairs. It is currently unknown how single or multiple non-G nucleotide insertions affect the stability or function of rG4s. Here, we investigated the G4-forming potential of GU- and GA-rich sequences by measuring their ability to inhibit ribosomal scanning and induce -1 ribosomal frameshifting (-1 FS) using a cell-free lysate. Our results show that, in contrast to canonical rG4s, GU and GA repeats with eight or more guanines do not affect ribosomal scanning or stimulate -1 FS. However, in the presence of G4-stabilizing ligands PhenDC3 or pyridostatin, GU and GA repeats strongly inhibited scanning and induced -1 FS. These findings have implications for the structural landscape of rG4s and the potential side-effects of G4 targeting drugs in general.
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