ArticleAnatolian journal of cardiology2025
Evaluation of Whole Blood Viscosity to Predict Stent Restenosis in Patients with Coronary Artery Disease.
Article in Anatolian journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Modulatory Effects of Clopidogrel on Vascular Response in the Human Internal Mammary Artery: An In Vitro Study.Anatolian journal of cardiology · 2026Article
- Assessment of the Association Between Whole Blood Viscosity and Coronary Artery Calcium Score.Medicina (Kaunas, Lithuania) · 2026Article
- Reply to Letter to the Editor: "Comments on 'Evaluation of Whole Blood Viscosity to Predict Stent Restenosis'".Anatolian journal of cardiology · 2025Article
- Comments on "Evaluation of Whole Blood Viscosity to Predict Stent Restenosis".Anatolian journal of cardiology · 2025Article
- Discrepancies in the Whole Blood Viscosity Formula: Which One is Correct?Anatolian journal of cardiology · 2025Article
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Authors and funding
7 authors.
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Abstract
backgroundThis study investigated the relationship between whole blood viscosity (WBV) and in-stent restenosis (ISR) in patients with prior coronary stent implantation who underwent coronary angiography (CAG) for chronic coronary syndrome (CCS).
methodsIn this retrospective case-control study, 802 patients who underwent CAG with suspected ISR were included. In-stent restenosis was defined as ≥50% stenosis within the stent or within 5 mm of its edges. Patients were divided into an ISR group (n = 342) and a control group without ISR (n = 460). Whole blood viscosity was calculated using both high-shear rate viscosity (HSR) and low-shear rate viscosity (LSR).
resultsWhole blood viscosity levels were significantly higher in the ISR group for both HSR (16.8 ± 1.0 vs. 15.6 ± 0.9 cP, P < .001) and LSR (83.1 ± 8.4 vs. 80.8 ± 8.0 cP, P < .001). Receiver-operating characteristic curve (ROC) analysis showed strong predictive power for ISR (area under the curve [AUC] 0.84 for LSR and 0.82 for HSR). Kaplan-Meier analysis demonstrated significantly lower ISR-free survival in patients with high WBV (P < .001). Multivariate Cox regression identified both HSR and LSR as independent predictors of ISR.
conclusionIncreased WBV is independently linked to ISR and may contribute to its development via endothelial inflammation and vascular remodeling. Whole blood viscosity demonstrates potential utility as a biomarker for the identification of CCS patients susceptible to ISR.
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