Evidence map›Paper›PMID 40454811›Full record

ArticlemBio2025

Host origin of microbiota drives functional recovery and

Sophie A Millard, Kimberly C Vendrov, Vincent B Young, Anna M Seekatz

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Recent advances in the positive role ofFrontiers in immunology · 2026
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sophie A MillardDepartment of Biological Sciences, Clemson University, Clemson, South Carolina, USA.ORCID 0009-0001-5522-9262
Kimberly C VendrovDivision of Infectious Disease, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9131-5272
Vincent B YoungDivision of Infectious Disease, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-3687-2364
Anna M SeekatzDepartment of Biological Sciences, Clemson University, Clemson, South Carolina, USA.ORCID 0000-0003-2586-7498

Funding

Regulation of Cryptosporidium DevelopmentP20GM146584 · NIGMS · CLEMSON UNIVERSITY · PI KERRY Scot SMITH · 2022 to 2026
$13.5M
Statistical Methods for Gene Regulatory Analysis From Single Cell Genomics DataP20GM139769 · NIGMS · CLEMSON UNIVERSITY · PI MACKAY, TRUDY F. · 2021 to 2025
$10.8M
Systems biology of Clostridium difficile infectionU01AI124255 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHLOSS, PATRICK DAVID, YOUNG, VINCENT B · 2016 to 2020
$9.8M
The Interplay Between Host Immunity and Clostridium difficile PathogenesisU19AI090871 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YOUNG, VINCENT B · 2010 to 2014
$7.5M
The microbiome and aging in Clostridioides difficile infectionR01AI162787 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YOUNG, VINCENT B, YUNG, RAYMOND L · 2022 to 2025
$3.0M
Niche Partitioning of Commensal Clostridia in the GutR35GM150609 · NIGMS · CLEMSON UNIVERSITY · PI Anna Maria Seekatz · 2023 to 2026
$1.5M
Critical functions of the gut microbiota that mediate recovery from recurrent Clostridium difficile infectionK01DK111794 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEEKATZ, ANNA MARIA · 2018 to 2022
$706k
NIAID NIH HHS R01 AI162787NIAID NIH HHS U01 AI124255NIAID NIH HHS U19 AI090871NIDDK NIH HHS K01 DK111794NIGMS NIH HHS P20 GM139769NIGMS NIH HHS P20 GM146584NIGMS NIH HHS R35 GM150609NIH HHS AI124255, AI090871NIH HHS K01-DK111794NIH HHS P20GM146584, P20GM139769
6 · The paper itself

Abstract

Colonization resistance provided by the gut microbiota is essential for resisting both initial IMPORTANCE:

Indexed as

Clostridioides difficileClostridium InfectionsFecal Microbiota TransplantationGastrointestinal MicrobiomeAnimalsDisease Models, AnimalFecesFemaleHumansMaleMetabolomicsMetagenomicsMiceMice, Inbred C57BLRNA, Ribosomal, 16SRNA, Ribosomal, 16SClostridioides difficilefecal microbiota transplantgut microbiomemetabolomicsmetagenomicsrecurrence

Identifiers

PMID40454811
PMCPMC12239565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.