ArticleEuropean journal of neurology2025
Cerebrospinal Fluid Phosphorylated Alpha-Synuclein in Newly Diagnosed Parkinson's Disease.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A Biological Framework for Parkinson's Disease: Advances in α-Synuclein-Centered Biomarkers and Staging.Journal of neurochemistry · 2026Review
- Alpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific Phenotypes.Cells · 2026Review
- Biomarkers for Lewy body diseases and other alpha-synucleinopathies in biofluids: current evidence and future directions.Journal of translational medicine · 2025Review
- Alpha-Synuclein Neurobiology in Parkinson's Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives.Brain sciences · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundAlpha-synuclein (α-syn), phosphorylated at serine 129 (pS129-α-syn), is a potential biomarker for Parkinson's disease (PD) because it is the predominant α-syn species found in Lewy bodies.
methodsWe developed an in-house SIMOA assay, using commercially available components, to quantify pS129-α-syn in CSF. The clinical utility of the assay was tested in CSF from 120 patients with PD from the Norwegian ParkWest longitudinal study and 29 normal controls. Prior measurements of CSF total (t)-α-syn and the pS129-α-syn/t-α-syn ratio were included for comparison.
resultsThe lower limit of quantification of the in-house assay used to analyze CSF samples from participants was 0.57 pg/mL, which was well below the observed concentrations of endogenous pS129-α-syn in CSF. Median CSF pS129-α-syn levels were slightly lower in PD patients compared to controls (5.7 pg/mL vs. 6.5 pg/mL), but the difference was not significant in the unadjusted (p = 0.404) or adjusted analyses (p = 0.270). There was no difference in the pS129-α-syn/t-α-syn ratio between patients and controls. Using linear mixed-effects models, we found no association between baseline pS129-α-syn or the pS129-α-syn/t-α-syn ratio and motor or cognitive decline over a 10-year period.
conclusionWe developed and applied an in-house SIMOA that reliably quantifies pS129-α-syn in CSF samples. This study does not indicate a role for CSF pS129-α-syn or the pS129-α-syn/t-α-syn ratio as clinically useful diagnostic or prognostic biomarkers in PD.
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Registered trials
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