ArticleAngewandte Chemie (International ed. in English)2025
Engineering a Multifunctional Nanozyme Platform for Synergistic Melanoma Therapy: Integrating Enzyme Activity, Immune Activation, and Low-Temperature Photothermal Effects.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Light as a master switch: a critical review of photonanozymes from design to applications.Advanced biotechnology · 2026Review
- Disease-Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- NIR-II Fluorescent Nanoplatforms with Defect-Regulated Piezoelectricity for Dual NIR-II/MRI-Guided, Hypoxia-Resilient Piezo-Chemodynamic Therapy and cGAS-STING Activation in Orthotopic Liver Tumor.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- From Cold to Hot: Nanozyme-Based Strategies for Reprogramming the Tumour Immunoenvironment.Cell proliferation · 2026Review
- Potentiating mild photothermal therapy via CDK12/13-mediated AKT suppression to orchestrate ferroptosis-apoptosis crosstalk for vaccine-like immunity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Photothermally-activated nano-delivery system for on-demand treatment of diabetic wound infections.International journal of pharmaceutics: X · 2026Article
- Glucose-responsive "sense-and-treat" microneedle patch for promoting diabetic chronic wound healing.Materials today. Bio · 2026Article
- A pH-responsive layered double hydroxide nanoradiosensitizer for bone metastasis tumor.Materials today. Bio · 2026Article
- Can nanozymes achieve more than enzymes?Nature reviews. Materials · 2026Article
- Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio-Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Decoding the spatiotemporal characteristics of ferroptosis: reshaping tumour therapeutic strategies.Experimental hematology & oncology · 2026Review
- From nanotechnology to immunomodulation: emerging strategies targeting macrophages in high altitude pulmonary hypertension.Journal of nanobiotechnology · 2026Review
- Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Selenium-derived bioactive enablers for advanced therapies: From molecular redox modulation to broad-spectrum disease applications.Bioactive materials · 2026Review
- Antioxidant Nanozymes: From Rational Design to Biomedical Applications.Research (Washington, D.C.) · 2026Review
- Precise Catalysis and Immune Activation: New Strategies for Tumor Immunotherapy with Cascade Nanozymes.International journal of nanomedicine · 2026Review
- Trimetallic Nanozyme-Embedded Smart Hydrogel Enables NIR-Controlled Bacterial Killing and Oxidative Stress Alleviation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Strategies for biofilm inhibition: the role of synthetic drug- and nanotechnology-based agents.Archives of microbiology · 2025Review
- Engineering a Multifunctional Nanozyme Platform for Synergistic Melanoma Therapy: Integrating Enzyme Activity, Immune Activation, and Low-Temperature Photothermal Effects.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Melanoma is characterized by rapid growth and high invasiveness, resulting in an exceptionally high malignancy and a significant propensity for metastasis. Current therapeutic modalities, such as chemotherapy and radiotherapy, exhibit limited efficacy due to severe side effects and immunosuppressive effects. Consequently, the development of precise and effective integrated therapeutic strategies is of paramount importance. Here, we report a multifunctional and multienzyme active nanosystem (FeCP@PDA-GOx) that synergistically integrates starvation therapy, chemodynamic therapy, mild photothermal therapy (mPTT), and immunotherapy to achieve multidimensional therapeutic effects. This nanoplatform harnesses the enzymatic activities of glucose oxidase, peroxidase, oxidase, and catalase to enhance tumor microenvironment modulation and drug delivery efficiency, ultimately inducing ferroptosis in tumor cells. The system also establishes a positive feedback loop to further amplify its catalytic performance. Additionally, it effectively suppresses the expression of heat shock proteins in tumor cells, thereby augmenting the therapeutic efficacy of mPTT. Moreover, the system activates robust immune responses, suppressing lung metastasis and eliciting systemic antitumor effects to inhibit the growth of distal tumors. Experimental results demonstrate that this multifunctional nanoplatform exhibits exceptional therapeutic efficacy and safety in melanoma treatment, laying a solid foundation for the advancement of personalized medicine and intelligent therapeutic strategies.
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Registered trials
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