ArticleAngewandte Chemie (International ed. in English)2025
Mechanochemistry-Driven Borrowing Hydrogen Processes for Ru-Catalyzed N-Alkylation: A Pathway to Enhanced Sustainability and Efficiency.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations.Angewandte Chemie (International ed. in English) · 2026Review
- Modular Generation of Alkyl Selenyl Radicals for the Synthesis of Alkyl Selenides via a Mechanochemical Approach.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mechanochemistry-Driven Borrowing Hydrogen Processes for Ru-Catalyzed N-Alkylation: A Pathway to Enhanced Sustainability and Efficiency.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
This study presents the first mechanochemical borrowing hydrogenation (BH) strategy, offering a direct and efficient route to N-alkylated amines and heterocycles. This solvent-free approach overcomes many challenges associated with conventional solution-based syntheses, such as toxic reagents, inert atmospheres, high temperatures, lengthy reaction times, excessive catalyst loadings, and the use of solvents. By applying this method under mechanochemical conditions and employing a readily available ruthenium-based catalyst, we achieved high conversions of a diverse set of primary amines and alcohols into N-alkylated amines. Furthermore, kinetic isotope effect (KIE) studies and Hammett analyses provided key insights into the underlying reaction mechanism. Ultimately, this protocol expands synthetic possibilities by facilitating the preparation of heterocycles.
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Registered trials
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