Evidence map›Paper›PMID 40454491›Full record

ArticleCurrent Alzheimer research2026

Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018.

Yan Chen, Jingyi Zhao, Chen Li, Yinhui Yao, Yazhen Shang

Abstract read
PubMed Publisher
In one paragraph

Article in Current Alzheimer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yan ChenInstitute of Traditional Chinese Medicine, Chengde Medical University, Chengde, 067000, China.
Jingyi ZhaoDepartment of Functional Center, Chengde Medical University, Chengde, 067000, China.
Chen LiInstitute of Traditional Chinese Medicine, Chengde Medical University, Chengde, 067000, China.
Yinhui YaoFaculty of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050200, China.
Yazhen ShangInstitute of Traditional Chinese Medicine, Chengde Medical University, Chengde, 067000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAt present, there is limited research on the association between dietary intake of anthocyanidins and Alzheimer's disease (AD). More epidemiological studies are needed to better understand this relationship.

methodsWe explored the relationship between dietary Anthocyanidins intake and AD among 3806 American adults in the National Health and Nutrition Examination Survey (NHANES) and the United States Department of Agriculture's Food and Nutrient Database for Dietary Studies (FNDDS) from 2007 to 2010, and 2017 to 2018. We use weighted logistic regression model, restricted cubic spline (RCS) and weighted quantile sum (WQS) regression analysis to analyze the relationship between anthocyanidins monomer and AD.

resultsThe weighted logistic regression model showed that the total intake of anthocyanidins was the fourth (OR:0.979; 95% CI: 0.966-0.992) quantile (relative to the lowest quantile) is related to the reduction of AD risk. RCS analysis showed that the total intake of anthocyanidins was negatively linearly correlated with AD (nonlinear P value was 0.002). The WQS regression analysis shows that cyanidin and malvidin are the main contributors to the comprehensive effects of six anthocyanidins. DISCUSSION: Our findings indicate that higher dietary anthocyanin intake may reduce the risk of AD and alleviate neurodegenerative processes. However, the mechanisms underlying this relationship remain unclear. Future studies should confirm these associations and investigate the relevant biological pathways.

conclusionOur results show that a higher dietary intake of anthocyanidins is associated with a lower risk of AD.

Indexed as

Alzheimer DiseaseAnthocyaninsDietAgedFemaleHumansMaleMiddle AgedNutrition SurveysRisk FactorsUnited StatesAnthocyaninsAlzheimer's diseaseAnthocyanidinsfood and nutrient database for dietary studiesnational health and nutrition examination surveyolderweighted quantile sum

Identifiers

PMID40454491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.