Evidence map›Paper›PMID 40454370›Full record

ArticleContact in context2024

Lack of Content Uniformity in Azacitidine Vials.

James T Isaacs, Philip J Almeter, Aaron N Hunter, Thomas A Lyman, Stephanie P Zapata, Bradley S Henderson, Seth A Larkin, Lindsey M Long, Megan N Bossle, Austin M Lozier and 15 more

Abstract read
In one paragraph

Article in Contact in context, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

James T IsaacsDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Philip J AlmeterDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Aaron N HunterDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Thomas A LymanDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Stephanie P ZapataDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Bradley S HendersonDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Seth A LarkinDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Lindsey M LongDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Megan N BossleDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Austin M LozierDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Joshua D MelsonDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Savannah R FraleyDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Eunice Hazzel L RelucioDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Margaret A FelixDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Jeffrey W ReynoldsDepartment of Finance, University of Kentucky HealthCare, Lexington, KY.
Ryan W NasemanDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Thomas L PlattDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Kaylee N MeadorPharmacy Practice & Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536.
Sanda GrahovicPharmacy Practice & Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536.
Jessica T RajcanPharmacy Practice & Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536.
Hyungjoo ShonPharmacy Practice & Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536.
Anna M CarlsonPharmacy Practice & Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536.
Taylor M FusonPharmacy Practice & Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536.
Lian Z HaneyPharmacy Practice & Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536.
Robert A LodderDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536.ORCID 0000-0001-6133-7561

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
NCATS NIH HHS UL1 TR001998
6 · The paper itself

Abstract

Azacitidine injections are used to treat specific types of blood cancers. They work by interfering with the growth of cancer cells. Azacitidine for injection is a nucleoside metabolic inhibitor indicated for the treatment of (a) Adult patients with the following FAB myelodysplastic syndrome (MDS) subtypes: Refractory anemia (RA) or refractory anemia with ringed sideroblasts (RARS) (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts (RAEB), refractory anemia with excess blasts in transformation (RAEB-T), and chronic myelomonocytic leukemia (CMMoL), and (b) Pediatric patients aged 1 month and older with newly diagnosed Juvenile Myelomonocytic Leukemia (JMML). Intra-lot variability was initially detected in one lot of azacitidine for injection in which 17% of the samples scanned in the lot were more than 5 multidimensional SDs from the center of the lot cluster. After the intra-lot variability was detected, inter-lot variability was measured in a spectral library comprising 8 lots of azacitidine for injection.

Identifiers

PMID40454370
PMCPMC12124808

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.