Evidence map›Paper›PMID 40454335›Full record

ArticleACS central science2025

Mechanism of O

Ioannis Kipouros, Hyeongtaek Lim, Mason J Appel, Katlyn K Meier, Britt Hedman, Keith O Hodgson, Carolyn R Bertozzi, Edward I Solomon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ioannis KipourosDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Hyeongtaek LimDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID https://orcid.org/0000-0003-3470-8296
Mason J AppelDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID https://orcid.org/0000-0001-7501-8115
Katlyn K MeierDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID https://orcid.org/0000-0002-8316-9199
Britt HedmanStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, California 94025, United States.
Keith O HodgsonDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Carolyn R BertozziDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID https://orcid.org/0000-0003-4482-2754
Edward I SolomonDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID https://orcid.org/0000-0003-0291-3199

Funding

Structure/Function Correlations Over Copper EnzymesR01DK031450 · NIDDK · STANFORD UNIVERSITY · PI EDWARD I SOLOMON · 1986 to 2026
$8.7M
NIDDK NIH HHS R01 DK031450
6 · The paper itself

Abstract

The formylglycine-generating enzyme (FGE) catalyzes the selective oxidation of a peptidyl-cysteine to form formylglycine, a critical cotranslational modification for type I sulfatase activation and a useful bioconjugation handle. Previous studies have shown that the substrate peptidyl-cysteine binds to the linear bis-thiolate Cu-(I) site of FGE to form a trigonal planar tris-thiolate Cu-(I) structure that activates O

Identifiers

PMID40454335
PMCPMC12123546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.