Perioperative Events Following Open Versus Endovascular Revascularization for Chronic Limb-Threatening Ischemia: An NSQIP Analysis.

Background: The Best Endovascular vs Best Surgical Therapy in Patients with Critical Limb Ischemia (BEST-CLI) trial reported the superiority of surgical bypass compared with endovascular intervention for the treatment of chronic limb-threatening ischemia (CLTI) in patients deemed suitable for either; however, the generalizability of these findings to the broader CLTI population is in question. Herein, we analyzed perioperative (30-day) outcomes from the National Surgical Quality Improvement Project (NSQIP) for CLTI interventions. Methods: The NSQIP-Vascular targeted database was queried from 2014 to 2019, contemporaneous with BEST-CLI, for patients undergoing CLTI intervention. Surgical bypass groups included saphenous vein (OPEN-GSV) or alternative conduit (OPEN-Other) and were compared to the endovascular (intervention group) (ENDO). Inverse Probability weighting with regression adjustment assessed 30-day outcomes including perioperative death (POD), major amputation, major adverse limb events (MALE, major reintervention and/or amputation), composite MALE or POD, and major adverse cardiovascular events (MACE, myocardial infarction, or stroke). Results were provided as risk ratio (RR). Results: Of the total cohort, 6780 (34.1%) were in the OPEN-GSV group, 4201 (21.1%) in OPEN-Other, and 8887 (44.7%) in ENDO. Compared to OPEN-GSV, ENDO exhibited a higher risk for major amputation (RR, 1.38; Conclusions: These data demonstrate a higher rate of early amputation and MALE among those who underwent ENDO vs OPEN-GSV. Conversely, early limb events were similar between ENDO and OPEN-Other. Both OPEN-GSV and OPEN-Other were associated with a higher risk of 30-day MACE. OPEN-Other was associated with a higher risk of MACE. These data highlight the importance of patient selection to optimize overall patient outcomes in CLTI.