Evidence map›Paper›PMID 40454255›Full record

ArticleAnesthesiology and pain medicine2025

Enhanced Postoperative Pain Management: A Comparative Analysis of Ultrasound-Guided Quadratus Lumborum Block Versus Intraperitoneal and Periportal Bupivacaine Infiltration Following Laparoscopic Cholecystectomy: A Randomized Double-Blind Study.

Ashraf Nabil Saleh, Sherif F Ibrahim, Yasmeen A Sayed, Mohammed Mawad Alsaid A, Karim Ahmed Sedky Abdelrahman, Mohamed Mahmoud Abdelaziz Aly, Mohammed Abdulgadir Ageel, Ahmed Gamal Salah Elsawy, Mohamed Elsayed Mahmoud, Amr M Hilal

Abstract read
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In one paragraph

Article in Anesthesiology and pain medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ashraf Nabil SalehDepartment of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-2282-3804
Sherif F IbrahimDepartment of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Yasmeen A SayedDepartment of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0009-0004-4122-1149
Mohammed Mawad Alsaid ADepartment of Anesthesia and Pain Management, Al-Fayoum University, Faiyum, Egypt.
Karim Ahmed Sedky AbdelrahmanDepartment of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mohamed Mahmoud Abdelaziz AlyDepartment of Anesthesia, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.
Mohammed Abdulgadir AgeelDepartment of Surgery, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia.
Ahmed Gamal Salah ElsawyDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0001-7075-7963
Mohamed Elsayed MahmoudDepartment of Anesthesia and Intensive, Faculty of Medicine, Luxor University, Luxor, Egypt.ORCID https://orcid.org/0009-0005-4467-3447
Amr M HilalDepartment of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Inadequately managed acute pain following abdominal surgery can lead to patient discomfort, anxiety, respiratory issues, delirium, myocardial ischemia, prolonged hospital stays, and persistent pain. Objectives: This research compares the quadratus lumborum (QL) block to intraperitoneal and periportal bupivacaine infiltration for postoperative analgesia after laparoscopic cholecystectomy. Methods: This randomized double-blind study included seventy patients aged 21 to 60 years, randomly selected from Ain Shams University Hospital between March 2022 and March 2023, scheduled for elective laparoscopic cholecystectomy. The patients were divided into two groups of 35 based on postoperative pain management: Group A received intraperitoneal and periportal infiltration, while group B underwent the QL block, with details on placement and duration. Results: The results indicated a substantial decrease in Visual Analogue Scale (VAS) scores at 6 hours postoperatively, with group B exhibiting a median pain level of 3 [IQR 3 - 5] compared to group A's median of 5 [IQR 5 - 6], yielding a P-value of less than 0.001. The data indicate that group B had significantly enhanced postoperative analgesia within the initial 6 hours, both in a static condition and during movement. Moreover, patients in group B required fewer postoperative analgesics during the first 24 hours following surgery compared to group A. Conclusions: Following laparoscopic cholecystectomy, the QL block proved more effective than intraperitoneal and periportal bupivacaine infiltration in reducing postoperative pain scores for 6 hours and in reducing total opioid and analgesic use for 24 hours postoperatively.

Indexed as

Intraperitoneal Bupivacaine InfiltrationLaparoscopic CholecystectomyPostoperative AnalgesiaQuadratus Lumborum Block

Identifiers

PMID40454255
PMCPMC12125661

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.