SynthesisFrontiers in neuroscience2025
Perturbations in gut microbiota in autism spectrum disorder: a systematic review.
Synthesis in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Plasma Metabolic Features Associated with Developmental Regression in Autism Spectrum Disorder: A Pilot Untargeted Metabolomics Study.International journal of molecular sciences · 2026Article
- Short-Chain Fatty Acid-Dependent Neuroimmune Regulation in Autism Spectrum Disorder Pathogenesis.The European journal of neuroscience · 2026Review
- Gut bacterial characteristics in children with autism spectrum disorder according to symptom severity: a cross-sectional study.BMC microbiology · 2026Observational
- Influence of Eating Behavior and Dietary Patterns on Gut Microbiota Formation in Children with Autism Spectrum Disorder.Nutrients · 2026Article
- Microbiome-Derived Short-Chain Fatty Acids and Tryptophan Metabolites in Children with Autism Spectrum Disorder: A Stool-Urine Multi-Omics Analysis.International journal of molecular sciences · 2026Article
- The Gut Microbiota and Autism Spectrum Disorder: Current Research and Therapeutic Insights.Behavioral sciences (Basel, Switzerland) · 2026Review
- Gut-Brain Inflammation and Disrupted Homeostasis Due to Activation of Mast Cells and Microglia.International journal of molecular sciences · 2026Review
- Microbiota-gut-brain axis and neuroendocrine pathways underlie divergent mechanisms of intermittent and continuous theta-burst stimulation in autism spectrum disorder.Cellular and molecular life sciences : CMLS · 2026Article
- Computational Identification of Blood-Brain Barrier-Permeant Microbiome Metabolites with Binding Affinity to Neurotransmitter Receptors in Neurodevelopmental Disorders.Molecules (Basel, Switzerland) · 2026Article
- The Vitamin D-Gut-Brain Axis in Autism Spectrum Disorder: A Bidirectional Crosstalk.International journal of general medicine · 2026Review
- Research progress on the microbiota-gut-brain axis in autism spectrum disorder: a narrative review.Frontiers in microbiology · 2026Review
- Early-life microbiota dysbiosis as a link between Autism Spectrum Disorder and Parkinson's Disease.Molecular psychiatry · 2026Article
- Washed microbiota transplantation improves clinical symptoms, gut microbiota, and metabolic profiles in autism spectrum disorder in a twin cohort.Frontiers in microbiology · 2026Article
- Gut Microbiota and Autism: Unlocking Connections.Nutrients · 2025Review
- Impact of maternal microbiota imbalance during pregnancy on fetal cerebral neurodevelopment: Is there a link to certain autistic disorders?Brain, behavior, & immunity - health · 2025Review
- The Prevalence and Clinical Significance of Toe Walking in Autism Spectrum Disorder: A Cross-Sectional Study in an Italian Pediatric Sample.Medicina (Kaunas, Lithuania) · 2025Observational
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Autism spectrum disorder (ASD) is a neurological and developmental disorder commonly accompanied by gut dysbiosis and gastrointestinal symptoms. Accumulating evidence supports a crucial role of gut microbiota dysbiosis in the pathophysiological mechanisms of ASD. However, the alteration of gut microbiota shows high heterogeneity across different studies. This study aims to identify potential biomarkers in the gut microbiota of patients with ASD. Methods: We conducted a comprehensive analysis by searching the PubMed, Web of Science, Cochrane Library, and Embase databases, for studies assessing the changes of gut microbial diversity and taxa in ASD patients and healthy controls using high-throughput sequencing. Vote counting analyses were performed to identify consistently altered gut microbes associated with ASD. Results: Sixty-four studies involving 189 differentially abundant gut microbial taxa were included. Our synthesis provided no strong evidence for a difference in α-diversity between ASD patients and healthy controls, while studies were relatively consistent in reporting differences in β-diversity. Among 189 taxa, we identified three significantly increased taxa in ASD patients: Eubacteriales, Conclusion: This systematic review contribute to a further understanding of the role of gut microbiota in ASD and support the development of microbiota-based diagnostic and therapeutic strategies for ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.