ArticleFrontiers in aging neuroscience2025
Radiological features of gait phenotypes in patients with idiopathic normal pressure hydrocephalus.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- MRI-based cerebrospinal fluid volumetric indices for predicting tap test response in idiopathic normal pressure hydrocephalus.Radiological physics and technology · 2026Observational
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12 authors.
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Abstract
Introduction: According to the higher-level gait disorder (HLGD) pattern, patients with idiopathic normal pressure hydrocephalus (iNPH) can be divided into two motor phenotypes; a disequilibrium (wide-based gait) subtype and a parkinsonian (locomotor) subtype. We aimed to understand the neuroimaging correlates of iNPH phenotyping into different gait patterns, by assessing specific radiological features and their correlations with clinical scores. Methods: We enrolled 86 probable iNPH patients (53 males; age range: 69-88 years), who underwent a comprehensive clinical assessment, including neuropsychological tests, and a conventional MRI scan. The cohort was subdivided into disequilibrium subtype (29 subjects) and parkinsonian subtype of HLGD (57 patients) based on gait evaluation. We compared the iNPH subtypes assessing differences in eight linear radiological indexes and their clinical correlates. Results: The Height of the third ventricle was the only radiological feature that differed between the two motor phenotypes ( Discussion: A greater height of the third ventricle possibly leading to a top-down compressive effect on the midbrain could be a neuroimaging marker of the parkinsonian phenotype of iNPH. The extensive correlations between linear radiological indices and clinical scales suggest a potential role for radiological features in clinical monitoring.
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