ArticleCancer management and research2025
A Comprehensive Study of Part-Solid Lung Adenocarcinoma with Lymph Node Metastasis: Clinical, Pathological, and Radiological Perspectives.
Article in Cancer management and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Conventional chest CT features are associated with Ki-67 labeling index in lung adenocarcinoma: a single-center retrospective radiopathologic study.Journal of thoracic disease · 2026Article
- Integrating deep learning and radiomics in the differentiation of major histological subtypes of invasive non-mucinous lung adenocarcinoma using positron emission tomography and computed tomography.Translational lung cancer research · 2025Article
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6 authors.
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Abstract
Purpose: Compared to solid lung adenocarcinomas (LUADs), part-solid LUADs rarely exhibit lymph node metastasis (LNM) and generally have a favorable prognosis. This study aims to comprehensively investigate the clinical, pathological, and CT characteristics of part-solid LUADs with LNM. Patients and Methods: This study collected 70 pathologically confirmed part-solid LUADs at two centers, including 35 cases with LNM and 35 matched cases without LNM based on size, CT pattern, and pathological subtype. Their clinical, pathological, and CT features were comprehensively analyzed and compared to identify the characteristics of part-solid LUADs associated with a high risk of LNM. Results: Among the 3,457 IACs manifested as part-solid lesions, a total of 35 (1.01%) cases were found to be associated with LNMs. Clinically, patients with and without LNM were similar. Pathologically, lesions exhibiting predominant micropapillary/solid pattern (11.4% vs 0.0%), and containing micropapillary (48.6% vs 25.7%) or any high-grade histological pattern were all more common in part-solid LUADs with LNM than in those without (each P < 0.05). Radiologically, solid components located at the tumor margins or distributed in a scattered manner (odds ratio [OR] = 4.048, P = 0.038) and consolidation-to-tumor ratio (CTR) > 57.2% (area) (OR = 45.649, P = 0.041) were independent predictors of LNM, with an area under the curve of this model being 0.881, sensitivity of 97%, and specificity of 77.1% (P < 0.001). Conclusion: LNM in part-solid LUADs is more prevalent in IACs with high-grade patterns, particularly the micropapillary pattern, with these lesions presenting as part-solid lesions that often have a larger CTR or distinct distribution of solid components.
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