Evidence map›Paper›PMID 40454092›Full record

ArticleiScience2025

Polycyclic aromatic hydrocarbons promote tumorigenesis of gallbladder cancer via aryl hydrocarbon Receptor-HEGBC positive feedback axis.

Lei Yuan, Yumeng Zhang, Jianguo Xu, Feng Liu, Yingchao Liang, Beili Wang, Meihong Wu, Zhiyuan Fan, Liang Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lei YuanDepartment of Hepatobiliary Surgery, Quzhou People's Hospital, 100 Minjiang Main Road, Quzhou, Zhejiang 324000, China.
Yumeng ZhangDepartment of Radiation Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.
Jianguo XuDepartment of Plastic Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Feng LiuDepartment of Scientific Research, Novel-Intel Biotech (Nanjing) Co., Ltd, Nanjing 211899, China.
Yingchao LiangDepartment of Radiation Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.
Beili WangDepartment of Radiation Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.
Meihong WuDepartment of Oncology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Zhiyuan FanDepartment of Breast Surgery, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.
Liang YangDepartment of Hepatobiliary Surgery, Quzhou People's Hospital, 100 Minjiang Main Road, Quzhou, Zhejiang 324000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gallbladder cancer (GBC) is a highly aggressive tumor associated with risk factors, such as chronic infection, gallstones, and exposure to harmful chemicals. Our study explores the role of polycyclic aromatic hydrocarbons (PAHs) and long noncoding RNA HEGBC in GBC progression. We found that PAHs activate the aryl hydrocarbon receptor (AhR), which enhances HEGBC expression and promotes GBC cell proliferation, invasion, and metastasis both

Indexed as

biological sciencescancer systems biologyhealth sciencesinternal medicinemedical specialtymedicinenatural sciencesoncologysystems biology

Identifiers

PMID40454092
PMCPMC12124655

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.