ArticleACS omega2025
Cellular Response to RGD Peptide Configuration on Gold Nanoparticles: A Surface Chemistry Investigation.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Advancing precision tumor therapy: Progress in targeted delivery of peptide-based nanomaterials from microenvironment to organelles.Materials today. Bio · 2026Review
- Building a Simple Platform for Tailoring Peptide Surface Chemistry to Enhance Cellular Uptake of Polymer-Coated Gold Nanoparticles.ACS omega · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biosystems are exceptional mechanisms for recognizing minute molecular differences in their processes, a principle upon which modern medicine is primarily built. Nanomaterials (NMs), unlike molecules, lack a definite shape and reactivity. Their surface chemical properties serve as the primary element of their behavior in biological environments. Therefore, it is essential to understand how molecular modifications on the surface of NMs influence their functions in biosystems to optimize their use in medical and biomedical applications. Gold nanoparticles (AuNPs) with well-defined surfaces are ideal for systematic surface chemistry studies due to their inertness and low toxicity. In this study, we examined the impact of molecular orientation differences in a peptide with a CRGD sequence and its reverse sequence, DGRC, on the cellular response of A549 (human Caucasian lung carcinoma) and BEAS-2b (human bronchial epithelial cell) cell lines. One end of the peptides contains a cysteine residue to ensure binding to 13 nm AuNP surfaces from that end. When the peptides are conjugated, two distinct surface chemistries are generated: in one case, a surface with one -NH
Identifiers
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Registered trials
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