Evidence map›Paper›PMID 40454035›Full record

ArticleACS omega2025

Rapid Equipment-Free Nucleic Acid Extraction Using a Silica-Based Pipet Tip Column.

Chaewon Jung, Gyeohoon Kim, Mun-Bum Song, Min-Gon Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chaewon JungDepartment of Chemistry, School of Physics and Chemistry, Gwangju Institute of Science & Technology (GIST), 123 Cheomdan-gwagiro, Gwangju 61005, Republic of Korea.ORCID https://orcid.org/0009-0007-4837-2953
Gyeohoon KimGMD Biotech., 416, Research Institute of University Industry Cooperation, Gwangju Institute of Science & Technology (GIST), 123 Cheomdan-gwagiro, Gwangju 61005, Republic of Korea.
Mun-Bum SongGMD Biotech., 416, Research Institute of University Industry Cooperation, Gwangju Institute of Science & Technology (GIST), 123 Cheomdan-gwagiro, Gwangju 61005, Republic of Korea.
Min-Gon KimDepartment of Chemistry, School of Physics and Chemistry, Gwangju Institute of Science & Technology (GIST), 123 Cheomdan-gwagiro, Gwangju 61005, Republic of Korea.ORCID https://orcid.org/0000-0002-3525-0048

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleic acid extraction from clinical specimens is essential for accurate molecular diagnostic assays. However, conventional extraction methods are often slow, equipment-dependent, and require trained personnel, limiting the point-of-care applicability. We introduce a novel silica-based pipet tip column that enables rapid nucleic acid extraction from clinical samples in less than 3 min. The pipet tip column has a large surface area for effective nucleic acid extraction using chaotropic salts. The integrated disposable 1 mL syringe eliminates the need for a pipet. Sample application is achieved by simply pushing and pulling the syringe, requiring no external power or specialized equipment. The pipet tip column performance was validated using standard influenza A and B, severe acute respiratory syndrome coronavirus-2, and Staphylococcus aureus samples, achieving high performance even at low concentrations (1 PFU/mL or 1 TCID

Identifiers

PMID40454035
PMCPMC12120609

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.