Evidence map›Paper›PMID 40454014›Full record

ArticleACS omega2025

From Nanocrystals and Nanocomposites to Microcrystals: The Role of Simonkolleite/ZnO in Overcoming Bacterial Resistance and Ensuring Biocompatibility.

Jerusa M de Oliveira, Maria P C Costa, Hugo F Perini, Rafael O Trevisan, Larissa I M de Almeida, Samanta L M de Matos, Isabella de O F de Sousa, Letícia C Ruiz, Leonardo E de A Silva, Virmondes Rodrigues and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jerusa M de OliveiraStrategic Materials Laboratory, Physics Institute, Federal University of Alagoas, Campus A. C. Simões. Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, Maceió 57072-970, Alagoas, Brazil.ORCID https://orcid.org/0000-0002-5337-0641
Maria P C CostaStrategic Materials Laboratory, Physics Institute, Federal University of Alagoas, Campus A. C. Simões. Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, Maceió 57072-970, Alagoas, Brazil.
Hugo F PeriniDepartment of Immunology, Microbiology and Parasitology, Federal University of Triângulo Mineiro, Av. Frei Paulino, no. 30Bairro Abadia, Uberaba 38025-180, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-1988-7273
Rafael O TrevisanDepartment of Immunology, Microbiology and Parasitology, Federal University of Triângulo Mineiro, Av. Frei Paulino, no. 30Bairro Abadia, Uberaba 38025-180, Minas Gerais, Brazil.
Larissa I M de AlmeidaStrategic Materials Laboratory, Physics Institute, Federal University of Alagoas, Campus A. C. Simões. Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, Maceió 57072-970, Alagoas, Brazil.
Samanta L M de MatosStrategic Materials Laboratory, Physics Institute, Federal University of Alagoas, Campus A. C. Simões. Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, Maceió 57072-970, Alagoas, Brazil.
Isabella de O F de SousaDepartment of Immunology, Microbiology and Parasitology, Federal University of Triângulo Mineiro, Av. Frei Paulino, no. 30Bairro Abadia, Uberaba 38025-180, Minas Gerais, Brazil.
Letícia C RuizDepartment of Immunology, Microbiology and Parasitology, Federal University of Triângulo Mineiro, Av. Frei Paulino, no. 30Bairro Abadia, Uberaba 38025-180, Minas Gerais, Brazil.
Leonardo E de A SilvaDepartment of Microbiology, Immunology and Parasitology, Federal University of Triângulo Mineiro, 100 Vigário Carlos St. 7o and 8o floor, Uberaba 38025-350, Minas Gerais, Brazil.
Virmondes RodriguesDepartment of Immunology, Microbiology and Parasitology, Federal University of Triângulo Mineiro, Av. Frei Paulino, no. 30Bairro Abadia, Uberaba 38025-180, Minas Gerais, Brazil.
Carlo J F de OliveiraDepartment of Immunology, Microbiology and Parasitology, Federal University of Triângulo Mineiro, Av. Frei Paulino, no. 30Bairro Abadia, Uberaba 38025-180, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-2211-7333
Marcos V da SilvaDepartment of Immunology, Microbiology and Parasitology, Federal University of Triângulo Mineiro, Av. Frei Paulino, no. 30Bairro Abadia, Uberaba 38025-180, Minas Gerais, Brazil.
Lucas AnheziniLaboratory of In Vivo Toxicity Analysis, Institute of Biological Sciences and Health, Federal University of Alagoas, Campus A. C. Simões. Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, Maceió 57072-970, Alagoas, Brazil.
Anielle Christine A SilvaStrategic Materials Laboratory, Physics Institute, Federal University of Alagoas, Campus A. C. Simões. Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, Maceió 57072-970, Alagoas, Brazil.ORCID https://orcid.org/0000-0002-5274-156X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents the innovative application of simonkolleite (SM), its nanocomposite with ZnO nanocrystals (NCs), and ZnO nano-/microcrystals to explore their bactericidal and biocompatibility properties for potential biomedical applications. A systematic evaluation of antibacterial activity, antibiofilm efficacy, reactive oxygen species (ROS) production, and Drosophila melanogaster as an in vivo model was performed. The synthesis of SM, SM/ZnO nanocomposites (NCPs), and ZnO nano- and microcrystals was performed at different annealing temperatures: SM at 100 °C, SM/Zn NCPs (63.6% and 69.5% of ZnO NCs) at 250 and 500 °C, respectively, and ZnO NCs and microcrystals (MCs) at 500 and 1000 °C, respectively. Notably, ZnO NCs and MCs have demonstrated pronounced cytotoxicity in the D. melanogaster model, correlating with their ability to rapidly generate reactive oxygen species (ROS), contributing to oxidative stress and cellular damage. The SM/ZnO NCPs (250 °C) exhibited superior biocompatibility, suggesting that the SM partial conversion to ZnO may mitigate toxicity while retaining antimicrobial efficacy. Furthermore, subinhibitory concentrations of SM effectively inhibited biofilm formation, a critical factor in bacterial resistance, highlighting their potential applications in medical device coatings and antimicrobial therapies. Collectively, this research underscores the promising role of these materials in addressing antibiotic resistance and enhancing biocompatibility in biomedical applications.

Identifiers

PMID40454014
PMCPMC12120594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.