ArticleAlzheimer's & dementia (New York, N. Y.)
Physical activity may mitigate sleep-related cognitive deficits in older adults: Findings from the IGNITE study.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Sex as a moderator of the association between cardiorespiratory fitness and depressive symptoms in older adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Trial
- Exercise, Sleep, and Cognitive Performance in Older Adults: A Structured Review of Mechanisms and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
- Physical activity, aerobic fitness, and AD blood biomarkers: The IGNITE study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The Lactate Nexus: A Molecular Bridge Linking Physical Activity, Sleep, and Cognitive Enhancement.Biomedicines · 2026Review
- Brain Glutathione Levels Associate With Cognitive Performance in Older Adults.Journal of neurochemistry · 2026Article
- Physical activity may mitigate sleep-related cognitive deficits in older adults: Findings from the IGNITE study.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
introductionPoor sleep is commonly associated with poorer cognition in older adults. Unfortunately, effective sleep improvement therapies for older adults are limited in their accessibility and have shown only subtle effects on cognition. Physical activity, however, is associated with better cognition in older adults and may compensate for cognitive deficits related to poor sleep. This study examined whether greater engagement in physical activity moderates the association between sleep and cognitive function in older adults. METHODOLOGY: We utilized baseline data from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) study. Cognitively unimpaired older adults (
resultsModerate-to-vigorous physical activity (MVPA) accumulated in at least 10-min bouts moderated the association between self-reported sleep efficiency and episodic memory, processing speed, executive function (EF)/attentional control, and working memory (β DISCUSSION: These results support the hypothesis that physical activity may mitigate the association between poor sleep and cognitive deficits in older adulthood. We highlight the need for further longitudinal studies and randomized clinical trials of exercise to further examine these associations. These results suggest that even small amounts of MVPA or light intensity physical activity mitigate the association between poor sleep and cognitive deficits in older adulthood. Highlights: Moderate-to-vigorous physical activity moderated the association of self-reported sleep efficiency with cognition.Light physical activity moderated the association of wake after sleep onset with cognition.Physical activity may mitigate sleep-related cognitive deficits in older adults.Further longitudinal studies and randomized controlled trials are needed.
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