ArticleJournal of inflammation research2025
Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Renoprotection by 5-Methoxytryptophan in Kidney Disease.Biomolecules · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Our study aims to investigate specific changes in serological 5-MTP expression in sepsis-associated acute kidney injury (SA-AKI) patients and assess its potential as a biomarker for SA-AKI occurrence. Additionally, we seek to evaluate the predictive value of 5-MTP in long-term clinical prognosis following SA-AKI. Patients and Methods: A prospective cohort study included 31 healthy controls and 78 patients diagnosed with sepsis at the Affiliated Hospital of Qinghai University. Following the collection of serological samples, 5-MTP levels were determined using targeted metabolomics.Additionally, we collected clinical data, including blood routine, biochemical, inflammatory indicators and severity of disease. Spearman correlation, COX regression analysis and Kaplan-Meier curves were used to evaluate the correlation between serum 5-MTP and renal function and the value of prognosis. Results: The findings revealed that serum 5-MTP levels were significantly elevated in SA-AKI patients compared to both the healthy control and sepsis groups( Conclusion: 5-MTP may have a protective role in the development of SA-AKI, and an early increase in serological expression of 5-MTP could positively impact the prognosis of sepsis and SA-AKI.
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