Evidence map›Paper›PMID 40453956›Full record

ArticleVeterinary world2025

Differential expression of

Nova Dilla Yanthi, Anneke Anggraeni, Syahruddin Said, Sugiyono Saputra, Retno Damayanti Soejoedono, Muladno Muladno, Nina Herlina, Ima Fauziah, Herjuno Ari Nugroho, Mukh Fajar Nasrulloh and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nova Dilla YanthiResearch Center for Applied Microbiology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency, Cibinong Science Center, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, Bogor 16911, West Java, Indonesia.
Anneke AnggraeniResearch Center for Animal Husbandry, Research Organization for Agriculture and Food, National Research and Innovation Agency, Cibinong Science Center, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, Bogor 16911, West Java, Indonesia.
Syahruddin SaidResearch Center for Applied Zoology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency, Cibinong Science Center, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, Bogor 16911, West Java, Indonesia.
Sugiyono SaputraResearch Center for Applied Microbiology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency, Cibinong Science Center, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, Bogor 16911, West Java, Indonesia.
Retno Damayanti SoejoedonoDivision of Medical Microbiology, School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University (IPB University), Jl. Agatis, Kampus IPB Dramaga, Bogor 16680, West Java, Indonesia.
Muladno MuladnoDepartment of Animal Production and Technology, Faculty of Animal Science, Bogor Agricultural University (IPB University), Jl. Agatis, Kampus IPB Dramaga, Bogor 16680, West Java, Indonesia.
Nina HerlinaResearch Center for Applied Zoology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency, Cibinong Science Center, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, Bogor 16911, West Java, Indonesia.
Ima FauziahResearch Centre for Veterinary Science, Research Organization for Health, National Research and Innovation Agency, Cibinong Science Center, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, Bogor 16911, West Java, Indonesia.
Herjuno Ari NugrohoResearch Center for Applied Microbiology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency, Cibinong Science Center, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, Bogor 16911, West Java, Indonesia.
Mukh Fajar NasrullohResearch Center for Applied Microbiology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency, Cibinong Science Center, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, Bogor 16911, West Java, Indonesia.
Rida TiffarentResearch Center for Applied Microbiology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency, Cibinong Science Center, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, Bogor 16911, West Java, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Mastitis remains a major health challenge in dairy cattle, often caused by Gram-positive pathogens. Toll-like receptors (TLRs) and chemokine receptors (CXCRs) play essential roles in the innate immune response of mammary epithelial cells (MECs). However, the differential expression of these genes in response to specific mastitis-causing Materials and Methods: HC11 cells were cultured and infected with Results: TLR2 exhibited a biphasic expression pattern, with early upregulation followed by suppression, while TLR4 showed higher expression in response to Conclusion: The immune response of HC11 MECs to Gram-positive bacterial infection is gene- and pathogen-specific.

Indexed as

Bacillus cereusBacillus subtilischemokine receptorsgene expressionHC11 cellsinnate immunitymastitistoll-like receptors

Identifiers

PMID40453956
PMCPMC12123283

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.