A Highly Sensitive Multiplex Antibody Assay Reduces Window Period for Detection of

Scott Meredith, Ankit Puri, Victoria F Majam, Hong Zheng, Miranda S Oakley, Laura Tonnetti, Susan L Stramer, Sanjai Kumar

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Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Scott MeredithLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.ORCID https://orcid.org/0000-0002-4415-8761

Ankit PuriLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

Victoria F MajamLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

Hong ZhengLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

Miranda S OakleyLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

Laura TonnettiAmerican Red Cross Holland Laboratory, Scientific Affairs, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0001-7735-8420

Susan L StramerInfectious Disease, North Potomac, Maryland, USA.

Sanjai KumarLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.ORCID https://orcid.org/0000-0001-6375-9354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The health burden of Methods: We developed a multiantigen, high-throughput, and highly sensitive Luminex bead-based assay (LBA) for detection of Results: Among the 4 antigens evaluated, MCFRP1 and BAHCS1 were the most sensitive biomarkers for Conclusions: Combination of these antigens in our LBA would reduce the window period before IFA-detectable seroconversion of detection in

Indexed as

Babesia microtilow-grade chronic infectionmultiplex antibody assayseroconversionwindow period

Identifiers

PMID40453878

DOI10.1093/ofid/ofaf253

PMCPMC12125675

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.