Evidence map›Paper›PMID 40453875›Full record

ArticleOpen forum infectious diseases2025

Temporal Changes in Nasopharyngeal Pneumococcal Colonization Density Associated With Respiratory Syncytial Virus and Influenza in a South African Household Cohort Study, 2016-2018.

Maimuna Carrim, Jackie Kleynhans, Stefano Tempia, Orienka Hellferscee, Florette K Treurnicht, Meredith L McMorrow, Jocelyn Moyes, Floidy Wafawanaka, Cheryl Cohen, Anne von Gottberg and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maimuna CarrimCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.ORCID https://orcid.org/0000-0003-2717-5540
Jackie KleynhansCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-7081-6273
Stefano TempiaCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.ORCID https://orcid.org/0000-0003-4395-347X
Orienka HellfersceeSchool of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Florette K TreurnichtSchool of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-0853-8011
Meredith L McMorrowInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-6363-4033
Jocelyn MoyesCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Floidy WafawanakaMRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Cheryl CohenCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.ORCID https://orcid.org/0000-0003-0376-2302
Anne von GottbergCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-0243-7455
Nicole WolterCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-9526-0133

Funding

Southern African-Pittsburgh Public Health Genomic Epidemiology Training Program (SAPPHGenE)D43TW011255 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Lee H Harrison, Anne von Gottberg · 2019 to 2026
$1.7M
FIC NIH HHS D43 TW011255Gates Foundation INV-010542NCIRD CDC HHS U51 IP000155
6 · The paper itself

Abstract

Background: Respiratory syncytial virus (RSV) and influenza infections are associated with increased pneumococcal colonization and disease risk. We assessed the impact of RSV and influenza on pneumococcal colonization density and factors influencing density changes during viral infection. Methods: Over 3 years, 1658 individuals from 325 households were enrolled, with nasopharyngeal swabs collected twice weekly for pneumococcus, RSV, and influenza A/B detection by real-time polymerase chain reaction. We analyzed samples from 2 weeks before, during, and 2 and 8 weeks after infection. Pneumococcal density was compared across infection periods by Results: Pneumococcal density increased during RSV infection (log mean before vs during infection, 9.3 vs 10.2 genomic copies/mL; Conclusions: RSV infection, especially with higher viral loads, increases pneumococcal colonization, while individuals who are underweight exhibit lower density changes.

Indexed as

community cohortinfluenzapneumococcus colonizationRSVStreptococcus pneumoniae

Identifiers

PMID40453875
PMCPMC12125651

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.