Evidence map›Paper›PMID 40453873›Full record

ArticleOpen forum infectious diseases2025

Trends in Incidence and Epidemiology of Methicillin-Resistant

Holly M Biggs, Rongxia Li, Kelly A Jackson, Joelle Nadle, Susan Petit, Susan M Ray, Ruth Lynfield, Kathryn Como-Sabetti, Ghinwa Dumyati, Anita Gellert and 4 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Methicillin-resistant Staphylococcus aureus.Nature reviews. Disease primers · 2026
    Review
  5. The global epidemiology of MRSA.JAC-antimicrobial resistance · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Monitoring the Burden ofAntibiotics (Basel, Switzerland) · 2026
    Article
  11. Population genomic variation inMicrobial genomics · 2026
    Article
  12. Hospital-onset methicillin-resistantInfection control and hospital epidemiology · 2026
    Article
  13. Trends, Seasonality, and the Impact of COVID-19 on ClinicalAntibiotics (Basel, Switzerland) · 2026
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Holly M BiggsDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-4949-2232
Rongxia LiDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-0664-4803
Kelly A JacksonDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-5398-0135
Joelle NadleCalifornia Emerging Infections Program, Oakland, California, USA.ORCID https://orcid.org/0009-0008-7874-7135
Susan PetitConnecticut Department of Public Health, Hartford, Connecticut, USA.
Susan M RayGeorgia Emerging Infections Program and Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-6327-088X
Ruth LynfieldMinnesota Department of Health, St. Paul, Minnesota, USA.
Kathryn Como-SabettiMinnesota Department of Health, St. Paul, Minnesota, USA.
Ghinwa DumyatiUniversity of Rochester Medical Center, Rochester, New York, USA.ORCID https://orcid.org/0000-0002-3634-2841
Anita GellertUniversity of Rochester Medical Center, Rochester, New York, USA.
Marissa WalshUniversity of Rochester Medical Center, Rochester, New York, USA.
William SchaffnerVanderbilt University School of Medicine, Nashville, Tennessee, USA.
James BaggsDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-0757-4683
Isaac SeeDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-6203-3084

Funding

NCEZID CDC HHS U50 CK000195NCEZID CDC HHS U50 CK000196NCEZID CDC HHS U50 CK000198NCEZID CDC HHS U50 CK000199NCEZID CDC HHS U50 CK000201NCEZID CDC HHS U50 CK000204
6 · The paper itself

Abstract

Background: The impact of the coronavirus disease 2019 (COVID-19) pandemic on methicillin-resistant Methods: Active laboratory- and population-based surveillance identified incident MRSA blood isolates among surveillance area residents in 6 continuously reporting sites during 2005-2022. Annual incidence per 100 000 census population was stratified by epidemiologic classification (hospital-onset, community-associated, health care-associated community-onset). Joinpoint with Poisson regression was used to determine incidence trend segments and annual percent change (APC; 2005-2019) and predicted incidence (2020-2022). Recent COVID-19 was a positive severe acute respiratory syndrome coronavirus 2 viral test ≤30 days before incident MRSA culture. Results: Overall declines in MRSA bacteremia incidence during 2005-2016 (APC, -7.1; Conclusions: Previous declines in MRSA bacteremia incidence had ended before the COVID-19 pandemic. During 2020-2022, patients with recent COVID-19 contributed substantially to increases in hospital-onset MRSA bacteremia, suggesting a need for robust infection prevention in this population. Reversal of prepandemic increases in health care-associated community-onset and community-associated infections during the pandemic could be related to COVID-19 mitigation measures.

Indexed as

bacteremiahealth care–associated infectionmethicillin-resistant Staphylococcus aureusStaphylococcus aureussurveillance

Identifiers

PMID40453873
PMCPMC12125674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.