ArticleOpen veterinary journal2025
The ameliorative effect of gallic acid and/or Lasix on topiramate-induced renal impairment in male rats.
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Topiramate (TPM) is commonly used for migraine prophylaxis; nonetheless, it is linked to nephrotoxicity, which mostly results from oxidative stress and inflammatory mechanisms. Aim: This study aimed to assess the preventive effects of gallic acid (GA) and furosemide (Lasix) against renal damage caused by TPM in rats. Methods: Sixty male albino rats were categorized into six groups: control, TPM-only, TPM + Lasix, Lasix-only, TPM + GA, and GA-only. The investigation lasted 60 days, evaluating renal function, oxidative stress indicators, and histological and immunohistochemical alterations. Results: The TPM-treated group exhibited considerable renal impairment, as indicated by increased levels of creatinine, urea, blood urea nitrogen, and interleukin (IL)-6, as well as reduced activity of antioxidant enzymes [catalase (CAT), superoxide dismutase]. Histopathological examination revealed tubular necrosis and inflammation, while immunohistochemistry results showed elevated expression of caspase3 and IL-6. The co-administration of GA or Lasix mitigated these effects. The TPM + GA group exhibited improved kidney function, less oxidative stress, and enhanced histological structure, underscoring GA's powerful antioxidant and anti-inflammatory characteristics. Likewise, Lasix exerted protective effects by alleviating TPM-induced kidney injury. Conclusion: These data highlight the therapeutic efficacy of GA and Lasix against TPM-induced nephrotoxicity, indicating their clinical relevance in addressing drug-induced kidney damage.
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