Evidence map›Paper›PMID 40453788›Full record

ArticleJournal of oral microbiology2025

Coaggregation of oral pathogens by postbiotic lactobacilli.

Patrick Golletz, Sissel Damsbo Jensen, Madeline Collignon, Charles Hall, Amanda Batoul Khamas, Andreas Møllebjerg, Sebastian Schlafer, Rikke Louise Meyer, Karolina Tykwinska

Abstract read
In one paragraph

Article in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Biofilm development ofMicrobiology spectrum · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Patrick GolletzNovozymes Berlin GmbH (Novonesis Group), Berlin, Germany.
Sissel Damsbo JensenInterdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
Madeline CollignonNovozymes Berlin GmbH (Novonesis Group), Berlin, Germany.
Charles HallNovonesis North America Inc, Franklinton, USA.
Amanda Batoul KhamasInterdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
Andreas MøllebjergInterdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
Sebastian SchlaferDepartment of Dentistry and Oral Health, Section for Oral Ecology, Cariology, Aarhus University, Aarhus, Denmark.
Rikke Louise MeyerInterdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
Karolina TykwinskaNovozymes Berlin GmbH (Novonesis Group), Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Coaggregation may reduce the abundance of bacteria in physiological fluids, such as saliva, as aggregated bacteria are cleared more easily than planktonic cells. This study aimed to identify Lactobacillus strains that coaggregate with oral pathogens with the perspective of using this approach to improve oral health. Material and methods: Coaggregation of 719 postbiotic Results: Two strains, Lacticaseibacillus rhamnosus 1B06 and Lacticaseibacillus paracasei 8A12, coaggregated efficiently with all three target pathogens and clinical isolates of the same species even in the presence of other salivary bacteria. The coaggregation capability of the selected Lactobacillus strains was unique and could not be reproduced with other genetically similar lactic acid bacteria of the same species. Conclusion: Lactobacillus strains capable of coaggregating oral pathogens were identified as promising candidates for the development of new postbiotic ingredients for oral hygiene products.

Indexed as

Fusobacterium nucleatumgingivitishalitosislactobacillusmalodororal healthPorhyromonas gingivalisPostbioticscreening

Identifiers

PMID40453788
PMCPMC12123943

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.