ArticleHealth science reports2025
Unveiling the Intricate Causal Nexus Between 91 Circulating Inflammatory Proteins and Perianal Abscess Through a Comprehensive Bidirectional Two-Sample Mendelian Randomization Analysis.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Unveiling the Intricate Causal Nexus Between 91 Circulating Inflammatory Proteins and Perianal Abscess Through a Comprehensive Bidirectional Two-Sample Mendelian Randomization Analysis.Health science reports · 2025Article
- Clarifying the Inflammatory Roots of Perianal Abscess: A Commentary on Mendelian Randomization Insights From 91 Circulating Proteins.Health science reports · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The link between circulating inflammatory proteins and perianal abscess remains uncertain. This study utilized the Mendelian randomization approach to examine the potential causality of 91 circulating inflammatory proteins in relation to perianal abscess (PA) and assessed the bidirectionality of these causal effects. Methods: We conducted analyses using Genome-wide Association Studies (GWAS) summary statistics for 91 circulating inflammatory proteins, sourced from 11 cohorts with a combined total of 14,824 participants. Genetic associations for PA were taken from the FinnGen Consortium R9 data, consisting of 2595 PA cases and 301,931 control individuals. Two-sample Mendelian randomization (MR) analysis was utilized to investigate the causal links between these inflammatory proteins and PA. To validate the reliability of our MR findings, sensitivity analyses were carried out. Furthermore, reverse Mendelian randomization was employed to assess whether there is evidence for a reciprocal causal effect. Results: Employing the inverse-variance weighted (IVW) approach, our findings identified 7 circulating inflammatory proteins with a potential causal link to PA. Notably, increased levels of interleukin-18 receptor 1 (OR = 1.10, 95% CI 1.01-1.19, Conclusions: Our Mendelian randomization analysis identifies a probable causal association involving 91 circulating inflammatory proteins and the risk of PA development.
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Registered trials
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