ArticleBioactive materials2025
Ultrasound-activated carrier-free nanoprodrugs enhanced universality and efficiency of solid tumor-targeting chemotherapy.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Ultrasound-Activated Prodrugs for Precision Cancer Therapy: From Mechanical and Cavitation Effects to Advanced Sonochemical Activation.Chem & bio engineering · 2026Review
- Ultrasound-triggered carrier-free nanoprodrugs activate cGAS-STING pathway to enhance tumor-targeting chemo-immunotherapy.Materials today. Bio · 2026Article
- Ultrasound-Boosted Liposomal Prodrug Overcomes Age-Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical outcome of chemotherapy for solid tumors is significantly restricted by adverse off-target side effects and heterogeneous microenvironments. Herein, we developed a series of ultrasound (US)-activated carrier-free self-assembled nanoprodrugs (PBSN38-OSs) to enhance universality and efficiency of tumor-targeting chemotherapy. The nanoprodrugs integrated reactive oxygen species (ROS)-responsive pinacol boronic ester-conjugated SN38 (PBSN38) and organic sonosensitizers (OSs). By screening the OSs library, six small molecules with strong binding ability with PBSN38 and high sonodynamic generation efficiency were identified. Then, various PBSN38-OSs nanoprodrugs with high drug-loading content and aqueous stability were fabricated using a facile nano-precipitation method. When exposed to US irradiation, PBSN38-OSs produced extensive ROS
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