Evidence map›Paper›PMID 40453695›Full record

ArticleBioactive materials2025

Human induced pluripotent stem cell derived nanovesicles for cardiomyocyte protection and proliferation.

Yuhua Wei, Xiaoxiao Geng, Qing You, Yu Zhang, Fangfang Cao, Gunaseelan Narayanan, Thanh Nguyen, Xiaoyuan Chen, Jianyi Zhang, Lei Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuhua WeiDepartment of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, 1190742, Singapore.
Xiaoxiao GengDepartment of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, 1190742, Singapore.
Qing YouDepartment of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, 1175753, Singapore.
Yu ZhangDepartment of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, 1175753, Singapore.
Fangfang CaoDepartment of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, 1175753, Singapore.
Gunaseelan NarayananDepartment of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 1175754, Singapore.
Thanh NguyenDepartment of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, 1190742, Singapore.
Xiaoyuan ChenDepartment of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, 1190742, Singapore.
Jianyi ZhangDepartment of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, 1190742, Singapore.
Lei YeDepartment of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, 1190742, Singapore.

Funding

Project 3 - Role of Proline Metabolism in Regulation of Mammalian Cardiomyocyte ProliferationP01HL160476 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Hesham Sadek · 2022 to 2026
$13.1M
NHLBI NIH HHS P01 HL160476
6 · The paper itself

Abstract

It remains a significant challenge to reactivate the cell cycle activity of adult mammalian cardiomyocytes (CMs). This study created a hypo-immunogenic human induced pluripotent stem cell (hiPSC) line using clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 gene editing to knockout β2-microglobulin in hiPSCs (

Indexed as

Cell cycleMyocardial protectionNanovesiclesPluripotent stem cellsRegeneration

Identifiers

PMID40453695
PMCPMC12124652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.