ReviewHealth promotion perspectives2025
Serum phospholipids during aging: A comprehensive systematic review of cross-sectional and case-control studies.
Review in Health promotion perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The lipidome, as a subset of metabolomics, can undergo significant variations due to several factors, including the aging process. Therefore, this study aims to summarize the relationship between aging and alterations in plasma phospholipids. Methods: A comprehensive search was conducted in MEDLINE (PubMed), Scopus, Embase, Web of Science, and Google Scholar databases up to September 2023. The PRISMA guidelines were adhered to throughout all stages of the review process. Cross-sectional and case-control studies that investigated the relationship between aging and phosphatidylcholine (PC), lysophosphatidylcholine (LPC), sphingomyelins (SM), ceramides, phosphatidylethanolamines (PE), and phosphatidylinositol (PI) were included. Results: A total of 8486 studies were identified, of which 32 met the predefined inclusion criteria. The systematic review included data from 70,499 participants. The findings revealed that four studies reported a positive association between PCs and aging in both sexes, while one study reported an inverse relationship. Additionally, two studies found that PCs were positively associated with aging in men and negatively associated in women. Furthermore, four studies indicated a negative association between PC metabolites and the aging process. With regard to LPCs, two studies demonstrated a positive correlation, and two studies showed an inverse correlation with aging in both sexes. For SMs, five studies reported a positive association, whereas two studies identified an inverse association with aging trends. Similarly, five studies reported a positive correlation between PE levels and aging, while two studies showed a negative correlation. Conclusion: Phospholipids play a critical role in the aging process, aging-related diseases, and the regulation of lifespan. A reduction in the levels of PCs and LPCs has been identified as a characteristic feature of aging.
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