ArticleFrontiers in pharmacology2025
Cold- and hot-classified botanical drugs differentially modulate gut microbiota: linking TCM emic classification to microbial ecology.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Traditional Uses, Phytochemistry, and Multi-Target Pharmacological Activities of Senna alexandrina.Chemistry & biodiversity · 2026Review
- Biophoton emission promotes the modern scientific utilization of medicinal plants: from theoretical integration to research applications.Frontiers in chemistry · 2025Review
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7 authors.
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Abstract
Introduction: Traditional Chinese Medicine (TCM) classifies botanical drugs based on their thermal properties (an emic classification system), categorizing them as "cold" (e.g., "clearing heat" for anti-inflammatory effects) or "hot" (e.g., "warming the middle" for metabolic enhancement). However, the specific roles of these botanical drugs in restoring gut microbiota dysbiosis remain unclear. This study aimed to explore whether TCM-classified cold and hot botanical drugs differentially restore gut microbiota dysbiosis and host physiology in antibiotic-treated mice. Methods: Mice with antibiotic-induced dysbiosis were treated with eight TCM-classified botanical drugs (four cold: Results: By day 20, all botanical drugs restored the diversity and ranking of dominant genera (those with >10% abundance, such as Discussion: TCM-classified cold and hot botanical drugs universally stabilize dominant microbiota while differentially modulating low-abundance taxa. The enrichment of
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