Evidence map›Paper›PMID 40453653›Full record

ArticleDrug target insights

Anti-Inflammatory and Regenerative Properties of Herbal Extracts: Wound Management in Equine Models.

Gustavo W Fehrenbach, Katie Sheils, Mariana J Silva, Jessica Walshe, Lena Madden, Ian Major, Niall Burke, Tim Yeomans, Emanuele Rezoagli, Emma J Murphy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug target insights. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gustavo W FehrenbachBioengineering Organ-on-Chip Research Group, Centre for Applied Bioscience Research, Technological University of the Shannon - Midwest Campus, Limerick - Ireland.ORCID https://orcid.org/0000-0002-9389-3391
Katie SheilsCentre for Applied Bioscience Research, Technological University of the Shannon - Midwest Campus, Limerick - Ireland.ORCID https://orcid.org/0000-0003-1603-8882
Mariana J SilvaBioengineering Organ-on-Chip Research Group, Centre for Applied Bioscience Research, Technological University of the Shannon - Midwest Campus, Limerick - Ireland.ORCID https://orcid.org/0009-0002-0035-5517
Jessica WalsheCentre for Applied Bioscience Research, Technological University of the Shannon - Midwest Campus, Limerick - Ireland.ORCID https://orcid.org/0000-0003-4354-6030
Lena MaddenCentre for Applied Bioscience Research, Technological University of the Shannon - Midwest Campus, Limerick - Ireland.ORCID https://orcid.org/0000-0002-1692-6954
Ian MajorBioengineering Organ-on-Chip Research Group, Centre for Applied Bioscience Research, Technological University of the Shannon - Midwest Campus, Limerick - Ireland.ORCID https://orcid.org/0000-0002-0538-9786
Niall BurkeCentre for Applied Bioscience Research, Munster Technological University, Kerry - Ireland.
Tim YeomansCentre for Applied Bioscience Research, Munster Technological University, Kerry - Ireland.
Emanuele RezoagliSchool of Medicine and Surgery, University of Milano-Bicocca, Fondazione IRCCS San Gerardo dei Tintori, Monza - Italy.ORCID https://orcid.org/0000-0002-4506-7212
Emma J MurphyBioengineering Organ-on-Chip Research Group, Centre for Applied Bioscience Research, Technological University of the Shannon - Midwest Campus, Limerick - Ireland.ORCID https://orcid.org/0000-0002-5620-0058

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Wound management presents significant challenges, requiring effective treatments. Herbal extracts have been traditionally used to support healing due to their anti-inflammatory, antimicrobial, and cell-regenerative properties. Methods: This study aimed to evaluate the therapeutic efficacy of Pau D'Arco ( Results: MTT assay was used to assess cytotoxicity. The extracts did not significantly affect the viability of HaCaT or THP-1 cells. The herbal extracts reduced IL-8 levels and increased phagocytic activity in macrophages, indicating an ability to modulate inflammatory responses. Conclusion: These findings suggest that the herbal extracts may be useful for supporting wound healing. Their natural anti-inflammatory and healing properties could provide an additional option alongside traditional wound management approaches.

Indexed as

Anti-inflammatory agentsHerbal extractsNatural compoundsSynergistic effectsTissue regenerationWound healing

Identifiers

PMID40453653
PMCPMC12124212

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.