ArticleNational science review2025
Live cell quantum multiphysiology enabled by a manipulable single nanodiamond.
Article in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The patch-clamp technique provides direct insight into electrophysiology. However, probing multiphysiology such as local temperature and electromagnetic field dynamics within a single live cell remains a challenge. Here we report live cell quantum multiphysiology using a manipulable-single-nanodiamond-based electron spin sensor. By electrically trapping and integrating a single nanodiamond onto a glass nanopipette, we achieve its 3D manipulation within a single live cell. This enables the first nanoscale controlled live cell quantum sensing of multiphysiology signals under native conditions, providing direct insight into localized intracellular activities. Our observations reveal a spatial heterogeneity in temperature over different sites within a single cell, indicative of local activity-induced heat production. Furthermore, temporally resolved relaxation measurements effectively capture the intracellular free-radical-mediated local electro-magnetic noise dynamics. We find a number of unexpected fluctuation phenomena of electromagnetic noise that may directly represent different types of intracellular free radical generation dynamics. Live cell quantum multiphysiology bridges the gap between high-physical-sensitivity-quantum sensing with high-spatiotemporal-resolution live cell measurements, opening up a new avenue for accessing cellular function with unprecedented capabilities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.