Evidence map›Paper›PMID 40453635›Full record

ArticleMethodist DeBakey cardiovascular journal2025

Hypercoagulability and the A1298C MTHFR Mutation: Case Series of Unexplained Pulmonary Embolism.

Akshat Sahai, Vaibhav Sharma, Prapti Mishra, Avinash Siddanoor, Abhishek Bhatia, Deepak Gargi Pande

Abstract readCase Reports
In one paragraph

Article in Methodist DeBakey cardiovascular journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akshat SahaiBLK-MAX Superspeciality Hospital, New Delhi, India.ORCID https://orcid.org/0009-0005-5969-622X
Vaibhav SharmaMedstar Washington Hospital Center, Washington, DC, USA.ORCID https://orcid.org/0009-0009-1471-354X
Prapti MishraBLK-MAX Superspeciality Hospital, New Delhi, India.ORCID https://orcid.org/0009-0006-1680-980X
Avinash SiddanoorBLK-MAX Superspeciality Hospital, New Delhi, India.ORCID https://orcid.org/0009-0007-3456-2422
Abhishek BhatiaBLK-MAX Superspeciality Hospital, New Delhi, India.ORCID https://orcid.org/0009-0009-7877-5395
Deepak Gargi PandeBLK-MAX Superspeciality Hospital, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methylenetetrahydrofolate reductase gene (

Indexed as

Blood CoagulationHyperhomocysteinemiaMethylenetetrahydrofolate Reductase (NADPH2)MutationPulmonary EmbolismThrombophiliaDNA Mutational AnalysisGenetic Predisposition to DiseaseHumansPhenotypeRisk FactorsMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanA1298C polymorphismhyperhomocysteinemiaMTHFR mutationpulmonary embolismthrombophiliavenous thromboembolism

Identifiers

PMID40453635
PMCPMC12124243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.