ArticleFrontiers in endocrinology2025
Association between estimated glucose disposal rate and preserved ratio impaired spirometry in adults.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Inflammation-Metabolism Axis in Preserved Ratio Impaired Spirometry: Pathogenic Mechanisms and Translational Implications.Journal of inflammation research · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Preserved ratio impaired spirometry (PRISm) is a newly defined phenotype of lung function impairment, characterized by a normal FEV1/FVC ratio alongside an FEV1/0.8 < FEV1 predicted value. Previous studies have linked PRISm to various adverse clinical outcomes, but its association with insulin resistance, as indicated by estimated glucose disposal rate (eGDR), remains underexplored. Methods: A total of 13,661 participants were included in this analysis after excluding individuals with missing data on PRISm (n = 10,954) and eGDR (n = 5,827). The median eGDR for the overall sample was calculated, and differences in baseline characteristics between the PRISm and non-PRISm groups were assessed. Logistic regression models were employed to analyze the relationship between eGDR and PRISm, adjusting for various confounders. Subgroup analyses were conducted based on gender and age. Additionally, the restricted cubic spline analysis was used to evaluate the non-linear relationship between eGDR and PRISm, and ROC analysis was performed to determine the predictive accuracy of eGDR for identifying PRISm. Results: Participants in the PRISm group exhibited significantly lower median eGDR values compared to the non-PRISm group (9.92 vs. 12.01 mg/kg/min; Conclusion: Our study demonstrates a significant inverse association between estimated glucose disposal rate (eGDR) and preserved ratio impaired spirometry (PRISm) among a diverse population of US adults. Participants with lower eGDR values exhibited a higher prevalence of PRISm, indicating greater insulin resistance and potential metabolic dysfunction. The findings suggest that eGDR may serve as a valuable marker for assessing the risk of PRISm, particularly among women and older adults.
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