Evidence map›Paper›PMID 40453567›Full record

ArticleClinical and translational radiation oncology2025

Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations.

Rutger Jan Cornelis de Koster, Jeremy Putra Gunawan, Hans Peters, Johan Bussink, Lara Barazzuol, Marc-Jan van Goethem, Alexander Gerbershagen, Robert Paul Coppes, Stefan Both

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Two-color spheroid model for determining the OJournal of biological engineering · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rutger Jan Cornelis de KosterParticle Therapy Research Center (PARTREC), University Medical Center Groningen, University of Groningen, The Netherlands.
Jeremy Putra GunawanParticle Therapy Research Center (PARTREC), University Medical Center Groningen, University of Groningen, The Netherlands.
Hans PetersDepartment of Radiation Oncology, Radboud University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Johan BussinkDepartment of Radiation Oncology, Radboud University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Lara BarazzuolParticle Therapy Research Center (PARTREC), University Medical Center Groningen, University of Groningen, The Netherlands.
Marc-Jan van GoethemParticle Therapy Research Center (PARTREC), University Medical Center Groningen, University of Groningen, The Netherlands.
Alexander GerbershagenParticle Therapy Research Center (PARTREC), University Medical Center Groningen, University of Groningen, The Netherlands.
Robert Paul CoppesParticle Therapy Research Center (PARTREC), University Medical Center Groningen, University of Groningen, The Netherlands.
Stefan BothParticle Therapy Research Center (PARTREC), University Medical Center Groningen, University of Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tissue sparing of ultra-high dose rate irradiation has been partially observed

Indexed as

HypoxiaOrganoidsUltra-high dose rate

Identifiers

PMID40453567
PMCPMC12123330

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.