Evidence map›Paper›PMID 40453557›Full record

ArticleCurrent sleep medicine reports2025

Daytime Napping in Adults: Benefits or Risks? Insights from Mendelian Randomization Studies.

Aarohi Gupta, Hassan S Dashti

Abstract read
In one paragraph

Article in Current sleep medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Optimal nap timing and body mass index: beyond duration.Journal of translational medicine · 2026
    Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aarohi GuptaDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Hassan S DashtiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Funding

The impact of overnight nutrition support on sleep and circadian rhythm disruption in the ICUR00HL153795 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DASHTI, HASSAN S. · 2023 to 2025
$747k
NHLBI NIH HHS R00 HL153795
6 · The paper itself

Abstract

Purpose of review: Daytime napping, a brief sleep episode during the day, has mixed health effects. This review explores the relationship between daytime napping frequency and health outcomes by synthesizing results from published Mendelian randomization (MR) studies, which help mitigate confounding and reverse causality commonly observed in traditional epidemiological research. Recent findings: A total of 35 studies spanning seven major disease categories were identified, with cardiovascular, neurological, and metabolic outcomes being the most frequently investigated in MR. Of the 89 tested outcomes, 36% of studies suggested increased disease risk with more frequent daytime napping, 54% reported no associations, and 10% suggested decreased disease risk with more frequent daytime napping. Not all MR findings align with existing epidemiological research. Summary: The current evidence from MR does not provide a definitive conclusion regarding the health effects of daytime napping. Future research should consider additional dimensions of napping beyond frequency and integrate both genetic and non-genetic approaches in diverse populations.

Indexed as

Daytime NappingGenome-wide Association StudiesHealth OutcomesMendelian Randomization

Identifiers

PMID40453557
PMCPMC12122017

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.