ArticleBiosafety and health2025
Host factor Rab4b promotes the replication of influenza A virus.
Article in Biosafety and health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rab proteins are involved in all facets of the vesicular transport process and play significant roles in different steps of the viral life cycle. Rab4b is a pivotal player in the endocytic recycling of proteins, whereas its roles in viral replication are still largely unknown. Our earlier work identified Rab4b as a host factor required to replicate the influenza A virus (IAV). Here, we further validated the impact of Rab4b on viral replication by silencing or overexpressing Rab4b. The results showed that silencing Rab4b significantly decreased IAV and influenza B virus (IBV) production. Overexpression of Rab4b enhanced IAV infection. We provided robust evidence to support the important role of Rab4b in facilitating IAV growth independent of the host innate immunity. Mechanism study revealed the involvement of Rab4b in the early steps of the IAV life cycle, including virus attachment, endocytosis of viral particles, virus-host membrane fusion, and nuclear import of viral nucleoprotein
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