Evidence map›Paper›PMID 40453362›Full record

ArticleGenes & diseases2025

The integration of single-cell RNA sequencing and spatial transcriptomics reveals the tumor microenvironment and spatial organization of testicular diffuse large B-cell lymphomas.

Xiaolong Wu, Jie Shi, Mujun Lu, Damin Yun, Sheng Gao, Longfei Hu, Fei Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaolong WuDepartment of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.
Jie ShiInstitute of Reproductive Medicine, Nantong University School of Medicine, Nantong, Jiangsu 226001, China.
Mujun LuDepartment of Urology and Andrology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.
Damin YunInstitute of Reproductive Medicine, Nantong University School of Medicine, Nantong, Jiangsu 226001, China.
Sheng GaoInstitute of Reproductive Medicine, Nantong University School of Medicine, Nantong, Jiangsu 226001, China.
Longfei HuSingleron Biotechnologies Ltd., 211 Pubin Road, Nanjing, Jiangsu 210061, China.
Fei SunDepartment of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary testicular diffuse large B-cell lymphomas (PT-DLBCL) are a collection of 1%-9% of testicular tumors. However, the characterization of the tumor microenvironment and spatial organization of PT-DLBCL is poorly understood. We profiled the transcriptomes of 19,559 single cells derived from a PT-DLBCL patient via single-cell RNA sequencing. We found that the tumor microenvironment was majorly composed of three exhausted CD8

Indexed as

CREBE2FPrimary testicular diffuse large B-cell lymphoma (PT-DLBCL)Single-cell RNA-seqSpatial transcriptomics

Identifiers

PMID40453362
PMCPMC12126957

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.